Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an SNCA mutation during development, to end-stage pathology is unknown. Utilisin...

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Detalles Bibliográficos
Autores principales: Virdi, Gurvir S., Choi, Minee L., Evans, James R., Yao, Zhi, Athauda, Dilan, Strohbuecker, Stephanie, Nirujogi, Raja S., Wernick, Anna I., Pelegrina-Hidalgo, Noelia, Leighton, Craig, Saleeb, Rebecca S., Kopach, Olga, Alrashidi, Haya, Melandri, Daniela, Perez-Lloret, Jimena, Angelova, Plamena R., Sylantyev, Sergiy, Eaton, Simon, Heales, Simon, Rusakov, Dmitri A., Alessi, Dario R., Kunath, Tilo, Horrocks, Mathew H., Abramov, Andrey Y., Patani, Rickie, Gandhi, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691718/
https://www.ncbi.nlm.nih.gov/pubmed/36424392
http://dx.doi.org/10.1038/s41531-022-00423-7

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