A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection

Entry of the hepatitis C virus (HCV) into host cells is a multistep process mediated by several host factors, including a tight junction protein claudin-1 (CLDN1). We repeatedly passaged HCV-JFH1-tau, an HCV substrain with higher infectivity, on Huh7.5.1-8 cells. A multi-passaged HCV-JFH1-tau lot wa...

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Detalles Bibliográficos
Autores principales: Shirasago, Yoshitaka, Fukazawa, Hidesuke, Nagase, Shotaro, Shimizu, Yoshimi, Mizukami, Tomoharu, Wakita, Takaji, Suzuki, Tetsuro, Tani, Hideki, Kondoh, Masuo, Kuroda, Takuya, Yasuda, Satoshi, Sato, Yoji, Hanada, Kentaro, Fukasawa, Masayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691748/
https://www.ncbi.nlm.nih.gov/pubmed/36424447
http://dx.doi.org/10.1038/s41598-022-23824-3

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