Cargando…

Cannabinoid receptor 2 (Cb2r) mediates cannabinol (CBN) induced developmental defects in zebrafish

Of the three primary cannabinoids in cannabis: Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD) and cannabinol (CBN), very little is known about the actions of CBN, the primary oxidative metabolite of THC. Our goal was to determine if CBN exposure during gastrulation alters embryonic developm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amin, Md Ruhul, Ahmed, Kazi Tanveer, Ali, Declan William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691751/ https://www.ncbi.nlm.nih.gov/pubmed/36424484 http://dx.doi.org/10.1038/s41598-022-23495-0

Ejemplares similares

Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid
por: Maioli, Chiara, et al.
Publicado: (2022)

Early Exposure to THC Alters M-Cell Development in Zebrafish Embryos
por: Amin, Md Ruhul, et al.
Publicado: (2020)

Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages
por: Gojani, Esmaeel Ghasemi, et al.
Publicado: (2023)

Motor neuron development in zebrafish is altered by brief (5-hr) exposures to THC (∆(9)-tetrahydrocannabinol) or CBD (cannabidiol) during gastrulation
por: Ahmed, Kazi T., et al.
Publicado: (2018)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
por: Polini, Beatrice, et al.
Publicado: (2020)

P066 A randomised, double-blind, placebo-controlled, single-dose, crossover, pilot study investigating the effects of cannabinol (CBN) 30 mg and 300 mg on sleep architecture and next-day function in insomnia disorder
por: Lavender, I, et al.
Publicado: (2022)

Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial
por: Lavender, Isobel, et al.
Publicado: (2023)

The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
por: Bow, Eric W., et al.
Publicado: (2016)

Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists
por: Navarro-Dorado, Jorge, et al.
Publicado: (2016)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
por: Bouskila, Joseph, et al.
Publicado: (2016)

Cannabinoid Receptor CB(2) Modulates Axon Guidance
por: Duff, Gabriel, et al.
Publicado: (2013)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
por: Smoum, Reem, et al.
Publicado: (2022)

Microglial Cannabinoid CB(2) Receptors in Pain Modulation
por: Xu, Kangtai, et al.
Publicado: (2023)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Effects of pro‐inflammatory cytokines on cannabinoid CB (1) and CB (2) receptors in immune cells
por: Jean‐Gilles, L., et al.
Publicado: (2015)

Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
por: Soderstrom, Ken, et al.
Publicado: (2017)

CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental Regulation
por: Van Waes, Vincent, et al.
Publicado: (2012)

Stimulation of cannabinoid receptor 2 (CB(2)) suppresses microglial activation
por: Ehrhart, Jared, et al.
Publicado: (2005)

Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS
por: Onaivi, E.S
Publicado: (2011)

Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor
por: Alapafuja, Shakiru O., et al.
Publicado: (2019)

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor
por: Morales, Paula, et al.
Publicado: (2020)

Cholesterol as a modulator of cannabinoid receptor CB(2) signaling
por: Yeliseev, Alexei, et al.
Publicado: (2021)

Structural basis of selective cannabinoid CB(2) receptor activation
por: Li, Xiaoting, et al.
Publicado: (2023)

Low Basal CB2R in Dopamine Neurons and Microglia Influences Cannabinoid Tetrad Effects
por: Liu, Qing-Rong, et al.
Publicado: (2020)

An Update on Non-CB(1), Non-CB(2) Cannabinoid Related G-Protein-Coupled Receptors
por: Morales, Paula, et al.
Publicado: (2017)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB(1)/CB(2) Receptor Interaction
por: Asproni, Battistina, et al.
Publicado: (2021)

The effects of subacute exposure to a water-soluble cannabinol compound in male mice
por: Bailey, Melissa M., et al.
Publicado: (2022)

Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson’s Disease In Vitro Model
por: Gugliandolo, Agnese, et al.
Publicado: (2023)

Developmental and Visual Input-Dependent Regulation of the CB1 Cannabinoid Receptor in the Mouse Visual Cortex
por: Yoneda, Taisuke, et al.
Publicado: (2013)

Antiallodynic Effects of Cannabinoid Receptor 2 (CB(2)R) Agonists on Retrovirus Infection-Induced Neuropathic Pain
por: Sheng, Wen S., et al.
Publicado: (2019)

Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos
por: Zuccarini, Giulia, et al.
Publicado: (2019)

Brain Cannabinoid CB(2) Receptors Modulate Cocaine’s Actions in Mice
por: Xi, Zheng-Xiong, et al.
Publicado: (2011)

Differential Activation of Intracellular versus Plasmalemmal CB(2) Cannabinoid Receptors
por: Brailoiu, G. Cristina, et al.
Publicado: (2014)

CB(2) Cannabinoid Receptor As Potential Target against Alzheimer's Disease
por: Aso, Ester, et al.
Publicado: (2016)

Cannabinoid CB(2) receptors in the mouse brain: relevance for Alzheimer’s disease
por: López, Alicia, et al.
Publicado: (2018)

Functional characterization of the novel cannabinoid receptor GPR55 and its modulation by CB(1 )and CB(2 )receptors
por: Balenga, Nariman, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_uogu89cjvfsl0v28a0dgdmdp3u