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Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

Highly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme of the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections and cancer. However, because DHODH inhibitors (DHODHi) are immunosuppressant...

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Detalles Bibliográficos
Autores principales:	Alkasalias, Twana, Zhang, Juan, Madapura, Harsha, Dalarun, Basile, Reina, Oscar Bedoya, Lewensohn, Rolf, Viktorsson, Kristina, Salihi, Abbas, Darekar, Suhas, Laín, Sonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691752/ https://www.ncbi.nlm.nih.gov/pubmed/36424385 http://dx.doi.org/10.1038/s41420-022-01254-4

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