Cargando…

Common recognition topology of mex transporters of Pseudomonas aeruginosa revealed by molecular modelling

The secondary transporters of the resistance-nodulation-cell division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria like Pseudomonas aeruginosa. Among these RND transporters, MexB, MexF, and MexY, with partly overlapping specificities, have been implicated in pathogenicity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Catte, Andrea, K. Ramaswamy, Venkata, Vargiu, Attilio Vittorio, Malloci, Giuliano, Bosin, Andrea, Ruggerone, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691783/ https://www.ncbi.nlm.nih.gov/pubmed/36438787 http://dx.doi.org/10.3389/fphar.2022.1021916

Ejemplares similares

Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa
por: Gervasoni, Silvia, et al.
Publicado: (2022)

Molecular Determinants of the Promiscuity of MexB and MexY Multidrug Transporters of Pseudomonas aeruginosa
por: Ramaswamy, Venkata K., et al.
Publicado: (2018)

Molecular determinants of avoidance and inhibition of Pseudomonas aeruginosa MexB efflux pump
por: Gervasoni, Silvia, et al.
Publicado: (2023)

Molecular rationale for the impairment of the MexAB-OprM efflux pump by a single mutation in MexA
por: Cacciotto, Pierpaolo, et al.
Publicado: (2021)

Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of Escherichia coli
por: Atzori, Alessio, et al.
Publicado: (2020)

A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds
por: Malloci, Giuliano, et al.
Publicado: (2015)

Tripartite efflux pumps of the RND superfamily: what did we learn from computational studies?
por: Athar, Mohd, et al.
Publicado: (2023)

Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters
por: Ramaswamy, Venkata Krishnan, et al.
Publicado: (2017)

AB-DB: Force-Field parameters, MD trajectories, QM-based data, and Descriptors of Antimicrobials
por: Gervasoni, Silvia, et al.
Publicado: (2022)

Interaction of Radiopharmaceuticals with Somatostatin Receptor 2 Revealed by Molecular Dynamics Simulations
por: Gervasoni, Silvia, et al.
Publicado: (2023)

A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones
por: Vergalli, Julia, et al.
Publicado: (2022)

Molecular simulations of SSTR2 dynamics and interaction with ligands
por: Gervasoni, Silvia, et al.
Publicado: (2023)

MexXY multidrug efflux system of Pseudomonas aeruginosa
por: Morita, Yuji, et al.
Publicado: (2012)

Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
por: Mehla, Jitender, et al.
Publicado: (2021)

Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence
por: Vaillancourt, Mylene, et al.
Publicado: (2021)

Time-Dependent Density Functional Theory Investigation on the Electronic and Optical Properties of Poly-C,Si,Ge-acenes
por: Mocci, Paola, et al.
Publicado: (2020)

siRNA-mediated gene silencing of MexB from the MexA-MexB-OprM efflux pump in Pseudomonas aeruginosa
por: Gong, Feng-Yun, et al.
Publicado: (2014)

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa
por: Horna, Gertrudis, et al.
Publicado: (2018)

In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa
por: Verchère, Alice, et al.
Publicado: (2014)

The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux
por: Vergalli, Julia, et al.
Publicado: (2020)

Evidence of MexT-Independent Overexpression of MexEF-OprN Multidrug Efflux Pump of Pseudomonas aeruginosa in Presence of Metabolic Stress
por: Kumar, Ayush, et al.
Publicado: (2011)

Antibiotic Inducibility of the mexXY Multidrug Efflux Operon of Pseudomonas aeruginosa: Involvement of the MexZ Anti-Repressor ArmZ
por: Hay, Thomas, et al.
Publicado: (2013)

Crystal Structure of the Regulatory Domain of MexT, a Transcriptional Activator of the MexEF-OprN Efflux Pump in Pseudomonas aeruginosa
por: Kim, Suhyeon, et al.
Publicado: (2019)

MexY-Promoted Aminoglycoside Resistance in Pseudomonas aeruginosa: Involvement of a Putative Proximal Binding Pocket in Aminoglycoside Recognition
por: Lau, Calvin Ho-Fung, et al.
Publicado: (2014)

A MexR Mutation Which Confers Aztreonam Resistance to Pseudomonas aeruginosa
por: Ma, Zhenzhen, et al.
Publicado: (2021)

Dissociation of minor groove binders from DNA: insights from metadynamics simulations
por: Vargiu, Attilio Vittorio, et al.
Publicado: (2008)

Pentachlorophenol Induction of the Pseudomonas aeruginosa mexAB-oprM Efflux Operon: Involvement of Repressors NalC and MexR and the Antirepressor ArmR
por: Starr, Lisa M., et al.
Publicado: (2012)

Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India
por: Choudhury, Debarati, et al.
Publicado: (2016)

Interaction of antibacterial compounds with RND eﬄux pumps in Pseudomonas aeruginosa
por: Dreier, Jürg, et al.
Publicado: (2015)

Berberine Derivatives as Pseudomonas aeruginosa MexXY-OprM Inhibitors: Activity and In Silico Insights
por: Giorgini, Giorgia, et al.
Publicado: (2021)

MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa
por: Ma, Miao, et al.
Publicado: (2021)

Overexpression of the MexXY Multidrug Efflux System Correlates with Deficient Pyoverdine Production in Pseudomonas aeruginosa
por: Ikarashi, Kei, et al.
Publicado: (2021)

Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter
por: Schulz, Robert, et al.
Publicado: (2015)

Correction: Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India
por: Choudhury, Debarati, et al.
Publicado: (2016)

Relation between Resistance to Antipseudomonal β-Lactams and ampC and mexC Genes of Pseudomonas aeruginosa
por: Rezaei, Fatemeh, et al.
Publicado: (2016)

Nucleotide substitutions in the mexR, nalC and nalD regulator genes of the MexAB-OprM efflux pump are maintained in Pseudomonas aeruginosa genetic lineages
por: Aguilar-Rodea, Pamela, et al.
Publicado: (2022)

Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa
por: Ntsogo Enguéné, Véronique Yvette, et al.
Publicado: (2015)

Expression of the MexXY-OprM efflux system in Pseudomonas aeruginosa with discordant cefepime/ceftazidime susceptibility profiles
por: Laohavaleeson, Somvadee, et al.
Publicado: (2008)

AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa
por: Lau, Calvin Ho-Fung, et al.
Publicado: (2015)

Role of the Multidrug Resistance Efflux Pump MexCD-OprJ in the Pseudomonas aeruginosa Quorum Sensing Response
por: Alcalde-Rico, Manuel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o09krpuq1ijqucbgofnugs810h