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Improving Solute Clearances by Hemodialysis
The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute mor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691790/ https://www.ncbi.nlm.nih.gov/pubmed/35613554 http://dx.doi.org/10.1159/000524512 |
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author | Lee, Seolhyun Sirich, Tammy L. Meyer, Timothy W. |
author_facet | Lee, Seolhyun Sirich, Tammy L. Meyer, Timothy W. |
author_sort | Lee, Seolhyun |
collection | PubMed |
description | The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be required to test the extent to which increasing the clearance on nonurea solutes with these various characteristics can improve patients' health. |
format | Online Article Text |
id | pubmed-9691790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-96917902022-05-25 Improving Solute Clearances by Hemodialysis Lee, Seolhyun Sirich, Tammy L. Meyer, Timothy W. Blood Purif Review − Advances in CKD 2022 The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be required to test the extent to which increasing the clearance on nonurea solutes with these various characteristics can improve patients' health. S. Karger AG 2022-05-25 /pmc/articles/PMC9691790/ /pubmed/35613554 http://dx.doi.org/10.1159/000524512 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Review − Advances in CKD 2022 Lee, Seolhyun Sirich, Tammy L. Meyer, Timothy W. Improving Solute Clearances by Hemodialysis |
title | Improving Solute Clearances by Hemodialysis |
title_full | Improving Solute Clearances by Hemodialysis |
title_fullStr | Improving Solute Clearances by Hemodialysis |
title_full_unstemmed | Improving Solute Clearances by Hemodialysis |
title_short | Improving Solute Clearances by Hemodialysis |
title_sort | improving solute clearances by hemodialysis |
topic | Review − Advances in CKD 2022 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691790/ https://www.ncbi.nlm.nih.gov/pubmed/35613554 http://dx.doi.org/10.1159/000524512 |
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