Cargando…

Improving Solute Clearances by Hemodialysis

The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute mor...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Seolhyun, Sirich, Tammy L., Meyer, Timothy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691790/
https://www.ncbi.nlm.nih.gov/pubmed/35613554
http://dx.doi.org/10.1159/000524512
_version_ 1784837106747572224
author Lee, Seolhyun
Sirich, Tammy L.
Meyer, Timothy W.
author_facet Lee, Seolhyun
Sirich, Tammy L.
Meyer, Timothy W.
author_sort Lee, Seolhyun
collection PubMed
description The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be required to test the extent to which increasing the clearance on nonurea solutes with these various characteristics can improve patients' health.
format Online
Article
Text
id pubmed-9691790
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-96917902022-05-25 Improving Solute Clearances by Hemodialysis Lee, Seolhyun Sirich, Tammy L. Meyer, Timothy W. Blood Purif Review − Advances in CKD 2022 The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be required to test the extent to which increasing the clearance on nonurea solutes with these various characteristics can improve patients' health. S. Karger AG 2022-05-25 /pmc/articles/PMC9691790/ /pubmed/35613554 http://dx.doi.org/10.1159/000524512 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Review − Advances in CKD 2022
Lee, Seolhyun
Sirich, Tammy L.
Meyer, Timothy W.
Improving Solute Clearances by Hemodialysis
title Improving Solute Clearances by Hemodialysis
title_full Improving Solute Clearances by Hemodialysis
title_fullStr Improving Solute Clearances by Hemodialysis
title_full_unstemmed Improving Solute Clearances by Hemodialysis
title_short Improving Solute Clearances by Hemodialysis
title_sort improving solute clearances by hemodialysis
topic Review − Advances in CKD 2022
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691790/
https://www.ncbi.nlm.nih.gov/pubmed/35613554
http://dx.doi.org/10.1159/000524512
work_keys_str_mv AT leeseolhyun improvingsoluteclearancesbyhemodialysis
AT sirichtammyl improvingsoluteclearancesbyhemodialysis
AT meyertimothyw improvingsoluteclearancesbyhemodialysis