Loss of seryl-tRNA synthetase (SARS1) causes complex spastic paraplegia and cellular senescence

BACKGROUND: Aminoacyl-tRNA synthetases (ARS) are key enzymes catalysing the first reactions in protein synthesis, with increasingly recognised pleiotropic roles in tumourgenesis, angiogenesis, immune response and lifespan. Germline mutations in several ARS genes have been associated with both recess...

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Detalles Bibliográficos
Autores principales: Verdura, Edgard, Senger, Bruno, Raspall-Chaure, Miquel, Schlüter, Agatha, Launay, Nathalie, Ruiz, Montserrat, Casasnovas, Carlos, Rodriguez-Palmero, Agustí, Macaya, Alfons, Becker, Hubert Dominique, Pujol, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Neurogenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691831/
https://www.ncbi.nlm.nih.gov/pubmed/36041817
http://dx.doi.org/10.1136/jmg-2022-108529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691831/
https://www.ncbi.nlm.nih.gov/pubmed/36041817
http://dx.doi.org/10.1136/jmg-2022-108529

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