Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus regulating pathological process. Studies have shown...

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Autores principales: Xu, Liangjie, Zhou, Cuicui, Liang, Yi, Fan, Tinpan, Zhang, Fen, Chen, Xinxin, Yuan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691837/
https://www.ncbi.nlm.nih.gov/pubmed/36439186
http://dx.doi.org/10.3389/fimmu.2022.1016870
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author Xu, Liangjie
Zhou, Cuicui
Liang, Yi
Fan, Tinpan
Zhang, Fen
Chen, Xinxin
Yuan, Wei
author_facet Xu, Liangjie
Zhou, Cuicui
Liang, Yi
Fan, Tinpan
Zhang, Fen
Chen, Xinxin
Yuan, Wei
author_sort Xu, Liangjie
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus regulating pathological process. Studies have shown that epigenetic modification contributes to the accumulation and function of MDSCs. This review summarizes the crosstalk between the epigenetic alterations and MDSCs functions, and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modification impact on the disease development, which represents as a promising therapeutic strategy for the related disorders.
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spelling pubmed-96918372022-11-26 Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells Xu, Liangjie Zhou, Cuicui Liang, Yi Fan, Tinpan Zhang, Fen Chen, Xinxin Yuan, Wei Front Immunol Immunology Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus regulating pathological process. Studies have shown that epigenetic modification contributes to the accumulation and function of MDSCs. This review summarizes the crosstalk between the epigenetic alterations and MDSCs functions, and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modification impact on the disease development, which represents as a promising therapeutic strategy for the related disorders. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9691837/ /pubmed/36439186 http://dx.doi.org/10.3389/fimmu.2022.1016870 Text en Copyright © 2022 Xu, Zhou, Liang, Fan, Zhang, Chen and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Liangjie
Zhou, Cuicui
Liang, Yi
Fan, Tinpan
Zhang, Fen
Chen, Xinxin
Yuan, Wei
Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title_full Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title_fullStr Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title_full_unstemmed Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title_short Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
title_sort epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691837/
https://www.ncbi.nlm.nih.gov/pubmed/36439186
http://dx.doi.org/10.3389/fimmu.2022.1016870
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