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Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection

Main protease (M(pro)) is a superior target for anti-SARS-COV-2 drugs. PF-07304814 is a phosphate ester prodrug of PF-00835231 that is rapidly metabolized into the active metabolite PF-00835231 by alkaline phosphatase (ALP) and then suppresses SARS-CoV-2 replication by inhibiting M(pro). PF-07304814...

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Detalles Bibliográficos
Autores principales:	Chen, Wujun, Shao, Yingchun, Peng, Xiaojin, Liang, Bing, Xu, Jiazhen, Xing, Dongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691842/ https://www.ncbi.nlm.nih.gov/pubmed/36438815 http://dx.doi.org/10.3389/fphar.2022.1035969

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