Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation

Most eukaryotic secretory proteins are cotranslationally translocated through Sec61 into the endoplasmic reticulum (ER). Because these proteins have evolved to fold in the ER, their mistargeting is associated with toxicity. Genetic experiments have implicated the ER heat shock protein 70 (Hsp70) Hsp...

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Detalles Bibliográficos
Autores principales: Espinoza, Mateo F., Nguyen, Khanh K., Sycks, Melody M., Lyu, Ziqi, Quanrud, Guy M., Montoya, Maureen R., Genereux, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691929/
https://www.ncbi.nlm.nih.gov/pubmed/36244454
http://dx.doi.org/10.1016/j.jbc.2022.102597

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