A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca(2+) channels

We recently reported the identification of a de novo single nucleotide variant in exon 9 of CACNA1C associated with prolonged repolarization interval. Recombinant expression of the glycine to arginine variant at position 419 produced a gain in the function of the L-type Ca(V)1.2 channel with increas...

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Detalles Bibliográficos
Autores principales: Zhao, Juan, Segura, Emilie, Marsolais, Mireille, Parent, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691931/
https://www.ncbi.nlm.nih.gov/pubmed/36273583
http://dx.doi.org/10.1016/j.jbc.2022.102632

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