Cargando…

Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol

Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart psychoactivity are assumed to predominantly function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghovanloo, Mohammad-Reza, Dib-Hajj, Sulayman D., Goodchild, Samuel J., Ruben, Peter C., Waxman, Stephen G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691960/ https://www.ncbi.nlm.nih.gov/pubmed/36439273 http://dx.doi.org/10.3389/fphys.2022.1066455

Ejemplares similares

Cannabidiol interactions with voltage-gated sodium channels
por: Sait, Lily Goodyer, et al.
Publicado: (2020)

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
por: Milligan, Carol J., et al.
Publicado: (2023)

Inhibitory effects of cannabidiol on voltage-dependent sodium currents
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development
por: Asiedu, Marina N., et al.
Publicado: (2017)

Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2016)

Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol
por: Mammana, Santa, et al.
Publicado: (2019)

Effective isolation of cannabidiol and cannabidiolic acid free of psychotropic phytocannabinoids from hemp extract by fast centrifugal partition chromatography
por: Maly, Matej, et al.
Publicado: (2023)

Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development
por: Akin, Elizabeth J., et al.
Publicado: (2015)

High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2023)

Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2021)

Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo
por: Fleisher-Berkovich, Sigal, et al.
Publicado: (2023)

Cannabidiol and Other Phytocannabinoids as Cancer Therapeutics
por: Nahler, Gerhard
Publicado: (2022)

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Nonmuscle myosin II isoforms interact with sodium channel alpha subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018)

Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations
por: Fux, Julia E., et al.
Publicado: (2018)

Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2022)

Life Cycle of the Cardiac Voltage-Gated Sodium Channel Na(V)1.5
por: Dong, Caijuan, et al.
Publicado: (2020)

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018)

Acute Cannabigerol Administration Lowers Blood Pressure in Mice
por: Vernail, Victoria L., et al.
Publicado: (2022)

Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels
por: Stephens, Robert F., et al.
Publicado: (2015)

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels
por: Amarouch, Mohamed-Yassine, et al.
Publicado: (2015)

Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota
por: Luz-Veiga, Mariana, et al.
Publicado: (2023)

Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives
por: Lőrincz, Eszter Boglárka, et al.
Publicado: (2023)

A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Voltage-Gated Channel Mechanosensitivity: Fact or Friction?
por: Morris, Catherine E.
Publicado: (2011)

Commentary: Voltage Gating of Mechanosensitive PIEZO Channels
por: Kaestner, Lars, et al.
Publicado: (2018)

KCNQs: Ligand- and Voltage-Gated Potassium Channels
por: Abbott, Geoffrey W.
Publicado: (2020)

Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
por: Bielawiec, Patrycja, et al.
Publicado: (2020)

Loss-of-function mutations of SCN10A encoding Na(V)1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease
por: Nettuwakul, Choochai, et al.
Publicado: (2018)

Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology
por: Edokobi, Nnamdi, et al.
Publicado: (2018)

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels
por: Lindner, Jamie S., et al.
Publicado: (2022)

A36 NON-PSYCHOTROPIC PHYTOCANNABINOIDS ATTENUATE VISCERAL HYPERSENSITIVITY IN DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS
por: Svendsen, K, et al.
Publicado: (2022)

Lacosamide Inhibition of Na(V)1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore
por: Labau, Julie I. R., et al.
Publicado: (2021)

Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA
por: Wroński, Adam, et al.
Publicado: (2023)

Na(v)1.7 is the predominant sodium channel in rodent olfactory sensory neurons
por: Ahn, Hye-Sook, et al.
Publicado: (2011)

Effects of ranolazine on wild-type and mutant hNa(v)1.7 channels and on DRG neuron excitability
por: Estacion, Mark, et al.
Publicado: (2010)

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7
por: Han, Chongyang, et al.
Publicado: (2007)

Cannabidiol and Cannabigerol Inhibit Cholangiocarcinoma Growth In Vitro via Divergent Cell Death Pathways
por: Viereckl, Michael J., et al.
Publicado: (2022)

Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol
por: Łuczaj, Wojciech, et al.
Publicado: (2023)

Voltage gated sodium channels in cancer and their potential mechanisms of action
por: Angus, Madeline, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lbp5else8456mkgtk77i00shlh