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Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both d...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691993/ https://www.ncbi.nlm.nih.gov/pubmed/36440214 http://dx.doi.org/10.3389/fendo.2022.958151 |
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author | Wu, Wenqi Gong, Tong Niu, Jinliang Li, Wenjin Li, Jianting Song, Xiaoli Cui, Sha Bian, Wenjin Wang, Jun |
author_facet | Wu, Wenqi Gong, Tong Niu, Jinliang Li, Wenjin Li, Jianting Song, Xiaoli Cui, Sha Bian, Wenjin Wang, Jun |
author_sort | Wu, Wenqi |
collection | PubMed |
description | Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both diffusion and perfusion quantifications without requiring intravenous contrast agent injection. In this prospective study, 60 healthy young age-matched volunteers (30 men and 30 women) underwent MRI scans at 1.5 T using multi–b-value diffusion-weighted imaging on sagittal planes covering the lumbar bone marrow. The apparent diffusion coefficient (ADC), true ADC (D), pseudo-ADC (D*), and perfusion fraction (f) were calculated from the diffusion-weighted images using the mono- and bi-exponential models. Lumbar cancellous bone (L2–L4) was selected as the region of interest. An independent t-test was used to detect significant differences in ADC values and IVIM parameters between men and women. The differences in IVIM parameters among the L2, L3, and L4 groups were compared with analysis of variance. The D and f values in women were significantly higher than that in men (p = 0.001, 0.026). However, D* was significantly lower in women than that in men (p = 0.001). Furthermore, there was no significant gender difference for the conventional ADC value (p = 0.186). Moreover, there were no significant differences in the D, f, and D* values among the L2, L3, and L4 vertebras of women or men. IVIM parameters can show differences in bone marrow between young women and men. As a non-invasive method, it can assess bone marrow microstructure, such as cellularity and perfusion. |
format | Online Article Text |
id | pubmed-9691993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96919932022-11-26 Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI Wu, Wenqi Gong, Tong Niu, Jinliang Li, Wenjin Li, Jianting Song, Xiaoli Cui, Sha Bian, Wenjin Wang, Jun Front Endocrinol (Lausanne) Endocrinology Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both diffusion and perfusion quantifications without requiring intravenous contrast agent injection. In this prospective study, 60 healthy young age-matched volunteers (30 men and 30 women) underwent MRI scans at 1.5 T using multi–b-value diffusion-weighted imaging on sagittal planes covering the lumbar bone marrow. The apparent diffusion coefficient (ADC), true ADC (D), pseudo-ADC (D*), and perfusion fraction (f) were calculated from the diffusion-weighted images using the mono- and bi-exponential models. Lumbar cancellous bone (L2–L4) was selected as the region of interest. An independent t-test was used to detect significant differences in ADC values and IVIM parameters between men and women. The differences in IVIM parameters among the L2, L3, and L4 groups were compared with analysis of variance. The D and f values in women were significantly higher than that in men (p = 0.001, 0.026). However, D* was significantly lower in women than that in men (p = 0.001). Furthermore, there was no significant gender difference for the conventional ADC value (p = 0.186). Moreover, there were no significant differences in the D, f, and D* values among the L2, L3, and L4 vertebras of women or men. IVIM parameters can show differences in bone marrow between young women and men. As a non-invasive method, it can assess bone marrow microstructure, such as cellularity and perfusion. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9691993/ /pubmed/36440214 http://dx.doi.org/10.3389/fendo.2022.958151 Text en Copyright © 2022 Wu, Gong, Niu, Li, Li, Song, Cui, Bian and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Wu, Wenqi Gong, Tong Niu, Jinliang Li, Wenjin Li, Jianting Song, Xiaoli Cui, Sha Bian, Wenjin Wang, Jun Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title | Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title_full | Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title_fullStr | Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title_full_unstemmed | Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title_short | Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI |
title_sort | study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted mri |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691993/ https://www.ncbi.nlm.nih.gov/pubmed/36440214 http://dx.doi.org/10.3389/fendo.2022.958151 |
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