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Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI

Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both d...

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Autores principales: Wu, Wenqi, Gong, Tong, Niu, Jinliang, Li, Wenjin, Li, Jianting, Song, Xiaoli, Cui, Sha, Bian, Wenjin, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691993/
https://www.ncbi.nlm.nih.gov/pubmed/36440214
http://dx.doi.org/10.3389/fendo.2022.958151
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author Wu, Wenqi
Gong, Tong
Niu, Jinliang
Li, Wenjin
Li, Jianting
Song, Xiaoli
Cui, Sha
Bian, Wenjin
Wang, Jun
author_facet Wu, Wenqi
Gong, Tong
Niu, Jinliang
Li, Wenjin
Li, Jianting
Song, Xiaoli
Cui, Sha
Bian, Wenjin
Wang, Jun
author_sort Wu, Wenqi
collection PubMed
description Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both diffusion and perfusion quantifications without requiring intravenous contrast agent injection. In this prospective study, 60 healthy young age-matched volunteers (30 men and 30 women) underwent MRI scans at 1.5 T using multi–b-value diffusion-weighted imaging on sagittal planes covering the lumbar bone marrow. The apparent diffusion coefficient (ADC), true ADC (D), pseudo-ADC (D*), and perfusion fraction (f) were calculated from the diffusion-weighted images using the mono- and bi-exponential models. Lumbar cancellous bone (L2–L4) was selected as the region of interest. An independent t-test was used to detect significant differences in ADC values and IVIM parameters between men and women. The differences in IVIM parameters among the L2, L3, and L4 groups were compared with analysis of variance. The D and f values in women were significantly higher than that in men (p = 0.001, 0.026). However, D* was significantly lower in women than that in men (p = 0.001). Furthermore, there was no significant gender difference for the conventional ADC value (p = 0.186). Moreover, there were no significant differences in the D, f, and D* values among the L2, L3, and L4 vertebras of women or men. IVIM parameters can show differences in bone marrow between young women and men. As a non-invasive method, it can assess bone marrow microstructure, such as cellularity and perfusion.
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spelling pubmed-96919932022-11-26 Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI Wu, Wenqi Gong, Tong Niu, Jinliang Li, Wenjin Li, Jianting Song, Xiaoli Cui, Sha Bian, Wenjin Wang, Jun Front Endocrinol (Lausanne) Endocrinology Bone marrow is one of the most important organs in the human body. The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. Intravoxel incoherent motion (IVIM) provides both diffusion and perfusion quantifications without requiring intravenous contrast agent injection. In this prospective study, 60 healthy young age-matched volunteers (30 men and 30 women) underwent MRI scans at 1.5 T using multi–b-value diffusion-weighted imaging on sagittal planes covering the lumbar bone marrow. The apparent diffusion coefficient (ADC), true ADC (D), pseudo-ADC (D*), and perfusion fraction (f) were calculated from the diffusion-weighted images using the mono- and bi-exponential models. Lumbar cancellous bone (L2–L4) was selected as the region of interest. An independent t-test was used to detect significant differences in ADC values and IVIM parameters between men and women. The differences in IVIM parameters among the L2, L3, and L4 groups were compared with analysis of variance. The D and f values in women were significantly higher than that in men (p = 0.001, 0.026). However, D* was significantly lower in women than that in men (p = 0.001). Furthermore, there was no significant gender difference for the conventional ADC value (p = 0.186). Moreover, there were no significant differences in the D, f, and D* values among the L2, L3, and L4 vertebras of women or men. IVIM parameters can show differences in bone marrow between young women and men. As a non-invasive method, it can assess bone marrow microstructure, such as cellularity and perfusion. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9691993/ /pubmed/36440214 http://dx.doi.org/10.3389/fendo.2022.958151 Text en Copyright © 2022 Wu, Gong, Niu, Li, Li, Song, Cui, Bian and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wu, Wenqi
Gong, Tong
Niu, Jinliang
Li, Wenjin
Li, Jianting
Song, Xiaoli
Cui, Sha
Bian, Wenjin
Wang, Jun
Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title_full Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title_fullStr Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title_full_unstemmed Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title_short Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI
title_sort study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted mri
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691993/
https://www.ncbi.nlm.nih.gov/pubmed/36440214
http://dx.doi.org/10.3389/fendo.2022.958151
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