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Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss

Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with potentiate damage to human health. Moreover, the...

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Autores principales: Zou, Mingshan, Huang, Mao, Zhang, Jianyun, Chen, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692084/
https://www.ncbi.nlm.nih.gov/pubmed/36438228
http://dx.doi.org/10.3389/fpubh.2022.1001760
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author Zou, Mingshan
Huang, Mao
Zhang, Jianyun
Chen, Rong
author_facet Zou, Mingshan
Huang, Mao
Zhang, Jianyun
Chen, Rong
author_sort Zou, Mingshan
collection PubMed
description Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with potentiate damage to human health. Moreover, their metabolites also show a serious potential contamination of soil, water, and air, leading to a serious impact on people's health. Hearing loss affects 430 million people (5.5% of the global population), bringing a heavy burden to individual patients and their families and society. However, the potential risk of hearing damage by OPs has not been taken seriously. In this study, we summarized the effects of OPs on hearing loss from epidemiological population studies and animal experiments. Furthermore, the possible mechanisms of OP-induced hearing loss are elucidated from oxidative stress, DNA damage, and inflammatory response. Overall, this review provides an overview of OP exposure alone or with noise that leads to hearing loss in human and experimental animals.
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spelling pubmed-96920842022-11-26 Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss Zou, Mingshan Huang, Mao Zhang, Jianyun Chen, Rong Front Public Health Public Health Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with potentiate damage to human health. Moreover, their metabolites also show a serious potential contamination of soil, water, and air, leading to a serious impact on people's health. Hearing loss affects 430 million people (5.5% of the global population), bringing a heavy burden to individual patients and their families and society. However, the potential risk of hearing damage by OPs has not been taken seriously. In this study, we summarized the effects of OPs on hearing loss from epidemiological population studies and animal experiments. Furthermore, the possible mechanisms of OP-induced hearing loss are elucidated from oxidative stress, DNA damage, and inflammatory response. Overall, this review provides an overview of OP exposure alone or with noise that leads to hearing loss in human and experimental animals. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9692084/ /pubmed/36438228 http://dx.doi.org/10.3389/fpubh.2022.1001760 Text en Copyright © 2022 Zou, Huang, Zhang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Zou, Mingshan
Huang, Mao
Zhang, Jianyun
Chen, Rong
Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title_full Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title_fullStr Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title_full_unstemmed Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title_short Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
title_sort exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692084/
https://www.ncbi.nlm.nih.gov/pubmed/36438228
http://dx.doi.org/10.3389/fpubh.2022.1001760
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