Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids

Cardiac reactive fibrosis is a fibroblast-derived maladaptive process to tissue injury that exacerbates an uncontrolled deposition of large amounts of extracellular matrix (ECM) around cardiomyocytes and vascular cells, being recognized as a pathological entity of morbidity and mortality. Cardiac fi...

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Detalles Bibliográficos
Autores principales: Tian, Yu, Tsujisaka, Yuta, Li, Vanessa Y., Tani, Kanae, Lucena-Cacace, Antonio, Yoshida, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692097/
https://www.ncbi.nlm.nih.gov/pubmed/36438566
http://dx.doi.org/10.3389/fcell.2022.1001453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692097/
https://www.ncbi.nlm.nih.gov/pubmed/36438566
http://dx.doi.org/10.3389/fcell.2022.1001453

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