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SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility

The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide...

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Autores principales: Rykova, Elena, Ershov, Nikita, Damarov, Igor, Merkulova, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692299/
https://www.ncbi.nlm.nih.gov/pubmed/36430200
http://dx.doi.org/10.3390/ijms232213725
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author Rykova, Elena
Ershov, Nikita
Damarov, Igor
Merkulova, Tatiana
author_facet Rykova, Elena
Ershov, Nikita
Damarov, Igor
Merkulova, Tatiana
author_sort Rykova, Elena
collection PubMed
description The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide polymorphisms (SNPs), which can change the binding affinity for target miRNAs leading to dysregulated gene expression. Accumulated data suggest that these SNPs can be associated with various human pathologies (cancer, diabetes, neuropsychiatric disorders, and cardiovascular diseases) by disturbing the interaction of miRNAs with their MREs located in mRNA 3′UTRs. Numerous data show the role of SNPs in 3′UTR MREs in individual drug susceptibility and drug resistance mechanisms. In this review, we brief the data on such SNPs focusing on the most rigorously proven cases. Some SNPs belong to conventional genes from the drug-metabolizing system (in particular, the genes coding for cytochromes P450 (CYP 450), phase II enzymes (SULT1A1 and UGT1A), and ABCB3 transporter and their expression regulators (PXR and GATA4)). Other examples of SNPs are related to the genes involved in DNA repair, RNA editing, and specific drug metabolisms. We discuss the gene-by-gene studies and genome-wide approaches utilized or potentially utilizable to detect the MRE SNPs associated with individual response to drugs.
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spelling pubmed-96922992022-11-26 SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility Rykova, Elena Ershov, Nikita Damarov, Igor Merkulova, Tatiana Int J Mol Sci Review The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide polymorphisms (SNPs), which can change the binding affinity for target miRNAs leading to dysregulated gene expression. Accumulated data suggest that these SNPs can be associated with various human pathologies (cancer, diabetes, neuropsychiatric disorders, and cardiovascular diseases) by disturbing the interaction of miRNAs with their MREs located in mRNA 3′UTRs. Numerous data show the role of SNPs in 3′UTR MREs in individual drug susceptibility and drug resistance mechanisms. In this review, we brief the data on such SNPs focusing on the most rigorously proven cases. Some SNPs belong to conventional genes from the drug-metabolizing system (in particular, the genes coding for cytochromes P450 (CYP 450), phase II enzymes (SULT1A1 and UGT1A), and ABCB3 transporter and their expression regulators (PXR and GATA4)). Other examples of SNPs are related to the genes involved in DNA repair, RNA editing, and specific drug metabolisms. We discuss the gene-by-gene studies and genome-wide approaches utilized or potentially utilizable to detect the MRE SNPs associated with individual response to drugs. MDPI 2022-11-08 /pmc/articles/PMC9692299/ /pubmed/36430200 http://dx.doi.org/10.3390/ijms232213725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rykova, Elena
Ershov, Nikita
Damarov, Igor
Merkulova, Tatiana
SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title_full SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title_fullStr SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title_full_unstemmed SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title_short SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
title_sort snps in 3′utr mirna target sequences associated with individual drug susceptibility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692299/
https://www.ncbi.nlm.nih.gov/pubmed/36430200
http://dx.doi.org/10.3390/ijms232213725
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