Cargando…

Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles

Biocompatible optical fibers and waveguides are gaining attention as promising platforms for implantable biophotonic devices. Recently, the distinct properties of silk fibroin were extensively explored because of its unique advantages, including flexibility, process compatibility, long-term biosafet...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Taeyoung, Cho, Yongjun, Yuk, Kyeong Min, Yu, Chan Yeong, Choi, Seung Ho, Byun, Kyung Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692301/
https://www.ncbi.nlm.nih.gov/pubmed/36433605
http://dx.doi.org/10.3390/s22229012
_version_ 1784837230049624064
author Kang, Taeyoung
Cho, Yongjun
Yuk, Kyeong Min
Yu, Chan Yeong
Choi, Seung Ho
Byun, Kyung Min
author_facet Kang, Taeyoung
Cho, Yongjun
Yuk, Kyeong Min
Yu, Chan Yeong
Choi, Seung Ho
Byun, Kyung Min
author_sort Kang, Taeyoung
collection PubMed
description Biocompatible optical fibers and waveguides are gaining attention as promising platforms for implantable biophotonic devices. Recently, the distinct properties of silk fibroin were extensively explored because of its unique advantages, including flexibility, process compatibility, long-term biosafety, and controllable biodegradability for in vitro and in vivo biomedical applications. In this study, we developed a novel silk fiber for a sensitive optical sensor based on surface-enhanced Raman spectroscopy (SERS). In contrast to conventional plasmonic nanostructures, which employ expensive and time-consuming fabrication processes, gold nanoparticles were uniformly patterned on the top surface of the fiber employing a simple and cost-effective convective self-assembly technique. The fabricated silk fiber-optic SERS probe presented a good performance in terms of detection limit, sensitivity, and linearity. In particular, the uniform pattern of gold nanoparticles contributed to a highly linear sensing feature compared to the commercial multi-mode fiber sample with an irregular and aggregated distribution of gold nanoparticles. Through further optimization, silk-based fiber-optic probes can function as useful tools for highly sensitive, cost-effective, and easily tailored biophotonic platforms, thereby offering new capabilities for future implantable SERS devices.
format Online
Article
Text
id pubmed-9692301
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96923012022-11-26 Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles Kang, Taeyoung Cho, Yongjun Yuk, Kyeong Min Yu, Chan Yeong Choi, Seung Ho Byun, Kyung Min Sensors (Basel) Article Biocompatible optical fibers and waveguides are gaining attention as promising platforms for implantable biophotonic devices. Recently, the distinct properties of silk fibroin were extensively explored because of its unique advantages, including flexibility, process compatibility, long-term biosafety, and controllable biodegradability for in vitro and in vivo biomedical applications. In this study, we developed a novel silk fiber for a sensitive optical sensor based on surface-enhanced Raman spectroscopy (SERS). In contrast to conventional plasmonic nanostructures, which employ expensive and time-consuming fabrication processes, gold nanoparticles were uniformly patterned on the top surface of the fiber employing a simple and cost-effective convective self-assembly technique. The fabricated silk fiber-optic SERS probe presented a good performance in terms of detection limit, sensitivity, and linearity. In particular, the uniform pattern of gold nanoparticles contributed to a highly linear sensing feature compared to the commercial multi-mode fiber sample with an irregular and aggregated distribution of gold nanoparticles. Through further optimization, silk-based fiber-optic probes can function as useful tools for highly sensitive, cost-effective, and easily tailored biophotonic platforms, thereby offering new capabilities for future implantable SERS devices. MDPI 2022-11-21 /pmc/articles/PMC9692301/ /pubmed/36433605 http://dx.doi.org/10.3390/s22229012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Taeyoung
Cho, Yongjun
Yuk, Kyeong Min
Yu, Chan Yeong
Choi, Seung Ho
Byun, Kyung Min
Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title_full Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title_fullStr Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title_full_unstemmed Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title_short Fabrication and Characterization of Novel Silk Fiber-Optic SERS Sensor with Uniform Assembly of Gold Nanoparticles
title_sort fabrication and characterization of novel silk fiber-optic sers sensor with uniform assembly of gold nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692301/
https://www.ncbi.nlm.nih.gov/pubmed/36433605
http://dx.doi.org/10.3390/s22229012
work_keys_str_mv AT kangtaeyoung fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles
AT choyongjun fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles
AT yukkyeongmin fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles
AT yuchanyeong fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles
AT choiseungho fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles
AT byunkyungmin fabricationandcharacterizationofnovelsilkfiberopticserssensorwithuniformassemblyofgoldnanoparticles