BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways

(1) Destabilization of microtubule dynamics is a primary strategy to inhibit fast growing tumor cells. The low cytotoxic derivative of microtubule inhibitor D-24851, named BPR0C261 exhibits antitumor activity via oral administration. In this study, we investigated if BPR0C261 could modulate the radi...

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Detalles Bibliográficos
Autores principales: Leu, Jyh-Der, Lin, Shih-Ting, Chen, Chiung-Tong, Chang, C.-Allen, Lee, Yi-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692308/
https://www.ncbi.nlm.nih.gov/pubmed/36430560
http://dx.doi.org/10.3390/ijms232214083

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