Computational Biology Dynamics of Mps1 Kinase Molecular Interactions with Isoflavones Reveals a Chemical Scaffold with Potential to Develop New Therapeutics for the Treatment of Cancer

The protein kinase Mps1 (monopolar spindle 1) is an important regulator of the Spindle Assembly Checkpoint (SAC), the evolutionary conserved checkpoint system of higher organisms that monitors the proper bipolar attachment of all chromosomes to the mitotic spindle during cell division. Defects in th...

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Detalles Bibliográficos
Autores principales: Pugh, Lauren, Pancholi, Alisha, Purat, Priscila Celeste, Agudo-Alvarez, Sandra, Benito-Arenas, Raúl, Bastida, Agatha, Bolanos-Garcia, Victor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692432/
https://www.ncbi.nlm.nih.gov/pubmed/36430712
http://dx.doi.org/10.3390/ijms232214228

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