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Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020)
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a common organism seen in both healthcare-associated and community-associated infections worldwide and in Malaysia over the past two decades. The aim of this review is to provide a firsthand documentation of all MRSA strains prevalent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692495/ https://www.ncbi.nlm.nih.gov/pubmed/36355902 http://dx.doi.org/10.3390/tropicalmed7110360 |
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author | Al-Talib, Hassanain Samsudin, Syahirah Adnan, Ariza Murugaiah, Chandrika |
author_facet | Al-Talib, Hassanain Samsudin, Syahirah Adnan, Ariza Murugaiah, Chandrika |
author_sort | Al-Talib, Hassanain |
collection | PubMed |
description | Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a common organism seen in both healthcare-associated and community-associated infections worldwide and in Malaysia over the past two decades. The aim of this review is to provide a firsthand documentation of all MRSA strains prevalent in the Malaysian population from 2002 to present and briefly describe the changing patterns. Methods: Electronic and manual intensive literature searches were conducted between 2002 and 2020, addressing issues directly related to patients and published in the English language were selected. Results: The literature search retrieved a total of 2217 articles and abstracts of 27 articles. The search yielded a total of 24 articles on genotyping of MRSA in Malaysia. The study found that MRSA strains were mostly genetically related and resulted in the predominant MRSA clones that caused active infections. Thirty-six different sequence types (ST) were recorded. The highest rates of STs detected were ST239 (52.6%), ST1 (47.4%), and ST22 (42.1%). The majority of studies showed that both SCCmec types III and IV were the most common SCCm type in Malaysia, followed by SCCmec type V (57.9%). Conclusions: Both Brazilian (ST 239 IIIA) and Hungarian (ST 239-III) MRSA strains were detected in Malaysia. PFGE remains the best method for comparing MRSA strains. However, whole-genome sequencing has a promising chance to replace PFGE in the future. |
format | Online Article Text |
id | pubmed-9692495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96924952022-11-26 Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) Al-Talib, Hassanain Samsudin, Syahirah Adnan, Ariza Murugaiah, Chandrika Trop Med Infect Dis Review Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a common organism seen in both healthcare-associated and community-associated infections worldwide and in Malaysia over the past two decades. The aim of this review is to provide a firsthand documentation of all MRSA strains prevalent in the Malaysian population from 2002 to present and briefly describe the changing patterns. Methods: Electronic and manual intensive literature searches were conducted between 2002 and 2020, addressing issues directly related to patients and published in the English language were selected. Results: The literature search retrieved a total of 2217 articles and abstracts of 27 articles. The search yielded a total of 24 articles on genotyping of MRSA in Malaysia. The study found that MRSA strains were mostly genetically related and resulted in the predominant MRSA clones that caused active infections. Thirty-six different sequence types (ST) were recorded. The highest rates of STs detected were ST239 (52.6%), ST1 (47.4%), and ST22 (42.1%). The majority of studies showed that both SCCmec types III and IV were the most common SCCm type in Malaysia, followed by SCCmec type V (57.9%). Conclusions: Both Brazilian (ST 239 IIIA) and Hungarian (ST 239-III) MRSA strains were detected in Malaysia. PFGE remains the best method for comparing MRSA strains. However, whole-genome sequencing has a promising chance to replace PFGE in the future. MDPI 2022-11-08 /pmc/articles/PMC9692495/ /pubmed/36355902 http://dx.doi.org/10.3390/tropicalmed7110360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Al-Talib, Hassanain Samsudin, Syahirah Adnan, Ariza Murugaiah, Chandrika Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title | Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title_full | Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title_fullStr | Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title_full_unstemmed | Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title_short | Genetic Diversity among Methicillin-Resistant Staphylococcus aureus in Malaysia (2002–2020) |
title_sort | genetic diversity among methicillin-resistant staphylococcus aureus in malaysia (2002–2020) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692495/ https://www.ncbi.nlm.nih.gov/pubmed/36355902 http://dx.doi.org/10.3390/tropicalmed7110360 |
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