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The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
The roles of medicinal plants or their purified bioactive compounds have attracted attention in the field of health sciences due to their low toxicity and minimal side effects. Baicalein is an active polyphenolic compound, isolated from Scutellaria baicalensis, and plays a significant role in the ma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692503/ https://www.ncbi.nlm.nih.gov/pubmed/36432119 http://dx.doi.org/10.3390/molecules27228023 |
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author | Rahmani, Arshad Husain Almatroudi, Ahmad Khan, Amjad Ali Babiker, Ali Yousif Alanezi, Malak Allemailem, Khaled S. |
author_facet | Rahmani, Arshad Husain Almatroudi, Ahmad Khan, Amjad Ali Babiker, Ali Yousif Alanezi, Malak Allemailem, Khaled S. |
author_sort | Rahmani, Arshad Husain |
collection | PubMed |
description | The roles of medicinal plants or their purified bioactive compounds have attracted attention in the field of health sciences due to their low toxicity and minimal side effects. Baicalein is an active polyphenolic compound, isolated from Scutellaria baicalensis, and plays a significant role in the management of different diseases. Epidemiologic studies have proven that there is an inverse association between baicalein consumption and disease severity. Baicalein is known to display anticancer activity through the inhibition of inflammation and cell proliferation. Additionally, the anticancer potential of baicalein is chiefly mediated through the modulation of various cell-signaling pathways, such as the induction of apoptosis, autophagy, cell cycle arrest, inhibition of angiogenesis, signal transducer and activator of transcription 3, and PI3K/Akt pathways, as well as the regulation of other molecular targets. Therefore, the current review aimed to explore the role of baicalein in different types of cancer along with mechanisms of action. Besides this, the synergistic effects with other anti-cancerous drugs and the nano-formulation based delivery of baicalein have also been discussed. |
format | Online Article Text |
id | pubmed-9692503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96925032022-11-26 The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways Rahmani, Arshad Husain Almatroudi, Ahmad Khan, Amjad Ali Babiker, Ali Yousif Alanezi, Malak Allemailem, Khaled S. Molecules Review The roles of medicinal plants or their purified bioactive compounds have attracted attention in the field of health sciences due to their low toxicity and minimal side effects. Baicalein is an active polyphenolic compound, isolated from Scutellaria baicalensis, and plays a significant role in the management of different diseases. Epidemiologic studies have proven that there is an inverse association between baicalein consumption and disease severity. Baicalein is known to display anticancer activity through the inhibition of inflammation and cell proliferation. Additionally, the anticancer potential of baicalein is chiefly mediated through the modulation of various cell-signaling pathways, such as the induction of apoptosis, autophagy, cell cycle arrest, inhibition of angiogenesis, signal transducer and activator of transcription 3, and PI3K/Akt pathways, as well as the regulation of other molecular targets. Therefore, the current review aimed to explore the role of baicalein in different types of cancer along with mechanisms of action. Besides this, the synergistic effects with other anti-cancerous drugs and the nano-formulation based delivery of baicalein have also been discussed. MDPI 2022-11-18 /pmc/articles/PMC9692503/ /pubmed/36432119 http://dx.doi.org/10.3390/molecules27228023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rahmani, Arshad Husain Almatroudi, Ahmad Khan, Amjad Ali Babiker, Ali Yousif Alanezi, Malak Allemailem, Khaled S. The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title | The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title_full | The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title_fullStr | The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title_full_unstemmed | The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title_short | The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways |
title_sort | multifaceted role of baicalein in cancer management through modulation of cell signalling pathways |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692503/ https://www.ncbi.nlm.nih.gov/pubmed/36432119 http://dx.doi.org/10.3390/molecules27228023 |
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