Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

Intracellular pathogens, such as Chlamydia trachomatis, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response of the host cells. Therefore, p53 reactivation by disruption of the p53–MDM2 complex could reduce infection and restore pro-apoptotic...

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Detalles Bibliográficos
Autores principales: Nuti, Elisa, La Pietra, Valeria, Daniele, Simona, Cuffaro, Doretta, Ciccone, Lidia, Giacomelli, Chiara, Cason, Carolina, Carotenuto, Alfonso, D’Amore, Vincenzo Maria, Pozzo, Eleonora Da, Costa, Barbara, Di Leo, Riccardo, Comar, Manola, Marinelli, Luciana, Martini, Claudia, Rossello, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692514/
https://www.ncbi.nlm.nih.gov/pubmed/36355491
http://dx.doi.org/10.3390/ph15111318

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