Cargando…

The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study

Background and Objectives: Considering the significant number of patients worldwide that received empirical antibiotic therapy for COVID-19 infection due to their critical condition and the lack of therapeutical guidelines, we wanted to find out the consequences of antibiotic use in our study popula...

Descripción completa

Detalles Bibliográficos
Autores principales: Iosub, Maria-Ilinca, Balan, Elena-Sabina, Pinte, Larisa, Draghici, Ana-Maria, Baicus, Cristian, Badea, Camelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692657/
https://www.ncbi.nlm.nih.gov/pubmed/36422168
http://dx.doi.org/10.3390/medicina58111628
_version_ 1784837322517250048
author Iosub, Maria-Ilinca
Balan, Elena-Sabina
Pinte, Larisa
Draghici, Ana-Maria
Baicus, Cristian
Badea, Camelia
author_facet Iosub, Maria-Ilinca
Balan, Elena-Sabina
Pinte, Larisa
Draghici, Ana-Maria
Baicus, Cristian
Badea, Camelia
author_sort Iosub, Maria-Ilinca
collection PubMed
description Background and Objectives: Considering the significant number of patients worldwide that received empirical antibiotic therapy for COVID-19 infection due to their critical condition and the lack of therapeutical guidelines, we wanted to find out the consequences of antibiotic use in our study population. Materials and Methods: We conducted a retrospective cohort study including symptomatic patients older than 18 years, hospitalized for SARS-CoV-2 between March and December 2020 in the Internal Medicine and Pneumology Departments of Colentina Clinical Hospital. The elected outcome was death, while independent variables were antibiotic therapy and literature-cited parameters associated with mortality in this disease. Results: Out of 198 included patients, 96 (48.48%) patients received antibiotic therapy during hospitalization. Female gender (OR = 2.61, p = 0.04), history of neoplasm (OR = 7.147, p = 0.01), heart failure (OR = 8.62, p = 0.002), and diabetes mellitus (OR = 3.05, p = 0.02) were significantly associated with death in multivariate analysis. Antibiotic treatment showed a higher probability of death both in bivariate (OR = 5.333, p < 0.001) and multivariate analysis adjusted for the aforementioned prognostic factors (OR = 3.55, p = 0.01). Conclusions: After adjusting for confounders, in-hospital antibiotic administration did not improve survival in COVID-19 patients.
format Online
Article
Text
id pubmed-9692657
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96926572022-11-26 The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study Iosub, Maria-Ilinca Balan, Elena-Sabina Pinte, Larisa Draghici, Ana-Maria Baicus, Cristian Badea, Camelia Medicina (Kaunas) Article Background and Objectives: Considering the significant number of patients worldwide that received empirical antibiotic therapy for COVID-19 infection due to their critical condition and the lack of therapeutical guidelines, we wanted to find out the consequences of antibiotic use in our study population. Materials and Methods: We conducted a retrospective cohort study including symptomatic patients older than 18 years, hospitalized for SARS-CoV-2 between March and December 2020 in the Internal Medicine and Pneumology Departments of Colentina Clinical Hospital. The elected outcome was death, while independent variables were antibiotic therapy and literature-cited parameters associated with mortality in this disease. Results: Out of 198 included patients, 96 (48.48%) patients received antibiotic therapy during hospitalization. Female gender (OR = 2.61, p = 0.04), history of neoplasm (OR = 7.147, p = 0.01), heart failure (OR = 8.62, p = 0.002), and diabetes mellitus (OR = 3.05, p = 0.02) were significantly associated with death in multivariate analysis. Antibiotic treatment showed a higher probability of death both in bivariate (OR = 5.333, p < 0.001) and multivariate analysis adjusted for the aforementioned prognostic factors (OR = 3.55, p = 0.01). Conclusions: After adjusting for confounders, in-hospital antibiotic administration did not improve survival in COVID-19 patients. MDPI 2022-11-11 /pmc/articles/PMC9692657/ /pubmed/36422168 http://dx.doi.org/10.3390/medicina58111628 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iosub, Maria-Ilinca
Balan, Elena-Sabina
Pinte, Larisa
Draghici, Ana-Maria
Baicus, Cristian
Badea, Camelia
The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title_full The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title_fullStr The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title_full_unstemmed The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title_short The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study
title_sort impact of antibiotic use on mortality in patients hospitalized in a covid-19 centre from romania: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692657/
https://www.ncbi.nlm.nih.gov/pubmed/36422168
http://dx.doi.org/10.3390/medicina58111628
work_keys_str_mv AT iosubmariailinca theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT balanelenasabina theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT pintelarisa theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT draghicianamaria theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT baicuscristian theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT badeacamelia theimpactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT iosubmariailinca impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT balanelenasabina impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT pintelarisa impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT draghicianamaria impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT baicuscristian impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy
AT badeacamelia impactofantibioticuseonmortalityinpatientshospitalizedinacovid19centrefromromaniaaretrospectivestudy