Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review

Depression is a globally widespread disorder caused by a complicated interplay of social, psychological, and biological factors. Approximately 280 million people are suffering from depression worldwide. Traditional frontline antidepressants targeting monoamine neurotransmitters show unsatisfactory e...

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Detalles Bibliográficos
Autores principales: Hu, Gonghui, Zhang, Meng, Wang, Yuyang, Yu, Ming, Zhou, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692659/
https://www.ncbi.nlm.nih.gov/pubmed/36430254
http://dx.doi.org/10.3390/ijms232213776
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author Hu, Gonghui
Zhang, Meng
Wang, Yuyang
Yu, Ming
Zhou, Yu
author_facet Hu, Gonghui
Zhang, Meng
Wang, Yuyang
Yu, Ming
Zhou, Yu
author_sort Hu, Gonghui
collection PubMed
description Depression is a globally widespread disorder caused by a complicated interplay of social, psychological, and biological factors. Approximately 280 million people are suffering from depression worldwide. Traditional frontline antidepressants targeting monoamine neurotransmitters show unsatisfactory effects. The development and application of novel antidepressants for dissimilar targets are on the agenda. This review characterizes the antidepressant effects of multiple endogenous compounds and/or their targets to provide new insight into the working mechanism of antidepressants. We also discuss perspectives and challenges for the generation of novel antidepressants.
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spelling pubmed-96926592022-11-26 Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review Hu, Gonghui Zhang, Meng Wang, Yuyang Yu, Ming Zhou, Yu Int J Mol Sci Review Depression is a globally widespread disorder caused by a complicated interplay of social, psychological, and biological factors. Approximately 280 million people are suffering from depression worldwide. Traditional frontline antidepressants targeting monoamine neurotransmitters show unsatisfactory effects. The development and application of novel antidepressants for dissimilar targets are on the agenda. This review characterizes the antidepressant effects of multiple endogenous compounds and/or their targets to provide new insight into the working mechanism of antidepressants. We also discuss perspectives and challenges for the generation of novel antidepressants. MDPI 2022-11-09 /pmc/articles/PMC9692659/ /pubmed/36430254 http://dx.doi.org/10.3390/ijms232213776 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Gonghui
Zhang, Meng
Wang, Yuyang
Yu, Ming
Zhou, Yu
Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title_full Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title_fullStr Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title_full_unstemmed Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title_short Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review
title_sort potential of heterogeneous compounds as antidepressants: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692659/
https://www.ncbi.nlm.nih.gov/pubmed/36430254
http://dx.doi.org/10.3390/ijms232213776
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