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Virtual Cocrystal Screening of Adefovir Dipivoxyl: Identification of New Solid Forms with Improved Dissolution and Permeation Profiles

The application of a computational screening methodology based on the calculation of intermolecular interaction energies has guided the discovery of new multicomponent solid forms of the oral antiviral Adefovir Dipivoxyl. Three new cocrystals with resorcinol, orcinol and hydroquinone have been synth...

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Detalles Bibliográficos
Autores principales:	Barbas, Rafael, Fael, Hanan, Lee, Samuel, Ruiz, Rebeca, Hunter, Christopher A., Fuguet, Elisabet, Ràfols, Clara, Prohens, Rafel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692677/ https://www.ncbi.nlm.nih.gov/pubmed/36365131 http://dx.doi.org/10.3390/pharmaceutics14112310

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