Cargando…
Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-bo...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692822/ https://www.ncbi.nlm.nih.gov/pubmed/36363799 http://dx.doi.org/10.3390/microorganisms10112206 |
_version_ | 1784837365438611456 |
---|---|
author | Li, Simin He, Mingxin Lei, Yumeng Liu, Yang Li, Xinquan Xiang, Xiaochen Wu, Qingming Wang, Qiang |
author_facet | Li, Simin He, Mingxin Lei, Yumeng Liu, Yang Li, Xinquan Xiang, Xiaochen Wu, Qingming Wang, Qiang |
author_sort | Li, Simin |
collection | PubMed |
description | Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-borne transmission under pathological circumstances. Certain bacteria drive tumorigenesis and progression through direct or indirect immune system actions. This review systemically discusses the recent advances in the field of oral microecology and tumor, including the oncogenic role of oral microbial abnormalities and various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, and carcinogen secretion) to introduce future directions for effective tumor prevention. |
format | Online Article Text |
id | pubmed-9692822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96928222022-11-26 Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis Li, Simin He, Mingxin Lei, Yumeng Liu, Yang Li, Xinquan Xiang, Xiaochen Wu, Qingming Wang, Qiang Microorganisms Review Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-borne transmission under pathological circumstances. Certain bacteria drive tumorigenesis and progression through direct or indirect immune system actions. This review systemically discusses the recent advances in the field of oral microecology and tumor, including the oncogenic role of oral microbial abnormalities and various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, and carcinogen secretion) to introduce future directions for effective tumor prevention. MDPI 2022-11-08 /pmc/articles/PMC9692822/ /pubmed/36363799 http://dx.doi.org/10.3390/microorganisms10112206 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Simin He, Mingxin Lei, Yumeng Liu, Yang Li, Xinquan Xiang, Xiaochen Wu, Qingming Wang, Qiang Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title | Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title_full | Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title_fullStr | Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title_full_unstemmed | Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title_short | Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis |
title_sort | oral microbiota and tumor—a new perspective of tumor pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692822/ https://www.ncbi.nlm.nih.gov/pubmed/36363799 http://dx.doi.org/10.3390/microorganisms10112206 |
work_keys_str_mv | AT lisimin oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT hemingxin oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT leiyumeng oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT liuyang oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT lixinquan oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT xiangxiaochen oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT wuqingming oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis AT wangqiang oralmicrobiotaandtumoranewperspectiveoftumorpathogenesis |