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Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis

Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-bo...

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Detalles Bibliográficos
Autores principales: Li, Simin, He, Mingxin, Lei, Yumeng, Liu, Yang, Li, Xinquan, Xiang, Xiaochen, Wu, Qingming, Wang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692822/
https://www.ncbi.nlm.nih.gov/pubmed/36363799
http://dx.doi.org/10.3390/microorganisms10112206
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author Li, Simin
He, Mingxin
Lei, Yumeng
Liu, Yang
Li, Xinquan
Xiang, Xiaochen
Wu, Qingming
Wang, Qiang
author_facet Li, Simin
He, Mingxin
Lei, Yumeng
Liu, Yang
Li, Xinquan
Xiang, Xiaochen
Wu, Qingming
Wang, Qiang
author_sort Li, Simin
collection PubMed
description Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-borne transmission under pathological circumstances. Certain bacteria drive tumorigenesis and progression through direct or indirect immune system actions. This review systemically discusses the recent advances in the field of oral microecology and tumor, including the oncogenic role of oral microbial abnormalities and various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, and carcinogen secretion) to introduce future directions for effective tumor prevention.
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spelling pubmed-96928222022-11-26 Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis Li, Simin He, Mingxin Lei, Yumeng Liu, Yang Li, Xinquan Xiang, Xiaochen Wu, Qingming Wang, Qiang Microorganisms Review Microorganisms have long been known to play key roles in the initiation and development of tumors. The oral microbiota and tumorigenesis have been linked in epidemiological research relating to molecular pathology. Notably, some bacteria can impact distal tumors by their gastrointestinal or blood-borne transmission under pathological circumstances. Certain bacteria drive tumorigenesis and progression through direct or indirect immune system actions. This review systemically discusses the recent advances in the field of oral microecology and tumor, including the oncogenic role of oral microbial abnormalities and various potential carcinogenesis mechanisms (excessive inflammatory response, host immunosuppression, anti-apoptotic activity, and carcinogen secretion) to introduce future directions for effective tumor prevention. MDPI 2022-11-08 /pmc/articles/PMC9692822/ /pubmed/36363799 http://dx.doi.org/10.3390/microorganisms10112206 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Simin
He, Mingxin
Lei, Yumeng
Liu, Yang
Li, Xinquan
Xiang, Xiaochen
Wu, Qingming
Wang, Qiang
Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title_full Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title_fullStr Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title_full_unstemmed Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title_short Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis
title_sort oral microbiota and tumor—a new perspective of tumor pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692822/
https://www.ncbi.nlm.nih.gov/pubmed/36363799
http://dx.doi.org/10.3390/microorganisms10112206
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