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The Role of Sfp1 in Candida albicans Cell Wall Maintenance

The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergo...

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Autores principales: Chang, Che-Kang, Yang, Min-Chi, Chen, Hsueh-Fen, Liao, Yi-Ling, Lan, Chung-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692975/
https://www.ncbi.nlm.nih.gov/pubmed/36422017
http://dx.doi.org/10.3390/jof8111196
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author Chang, Che-Kang
Yang, Min-Chi
Chen, Hsueh-Fen
Liao, Yi-Ling
Lan, Chung-Yu
author_facet Chang, Che-Kang
Yang, Min-Chi
Chen, Hsueh-Fen
Liao, Yi-Ling
Lan, Chung-Yu
author_sort Chang, Che-Kang
collection PubMed
description The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response.
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spelling pubmed-96929752022-11-26 The Role of Sfp1 in Candida albicans Cell Wall Maintenance Chang, Che-Kang Yang, Min-Chi Chen, Hsueh-Fen Liao, Yi-Ling Lan, Chung-Yu J Fungi (Basel) Article The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response. MDPI 2022-11-13 /pmc/articles/PMC9692975/ /pubmed/36422017 http://dx.doi.org/10.3390/jof8111196 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Che-Kang
Yang, Min-Chi
Chen, Hsueh-Fen
Liao, Yi-Ling
Lan, Chung-Yu
The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title_full The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title_fullStr The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title_full_unstemmed The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title_short The Role of Sfp1 in Candida albicans Cell Wall Maintenance
title_sort role of sfp1 in candida albicans cell wall maintenance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692975/
https://www.ncbi.nlm.nih.gov/pubmed/36422017
http://dx.doi.org/10.3390/jof8111196
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