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The Role of Sfp1 in Candida albicans Cell Wall Maintenance
The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692975/ https://www.ncbi.nlm.nih.gov/pubmed/36422017 http://dx.doi.org/10.3390/jof8111196 |
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author | Chang, Che-Kang Yang, Min-Chi Chen, Hsueh-Fen Liao, Yi-Ling Lan, Chung-Yu |
author_facet | Chang, Che-Kang Yang, Min-Chi Chen, Hsueh-Fen Liao, Yi-Ling Lan, Chung-Yu |
author_sort | Chang, Che-Kang |
collection | PubMed |
description | The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response. |
format | Online Article Text |
id | pubmed-9692975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96929752022-11-26 The Role of Sfp1 in Candida albicans Cell Wall Maintenance Chang, Che-Kang Yang, Min-Chi Chen, Hsueh-Fen Liao, Yi-Ling Lan, Chung-Yu J Fungi (Basel) Article The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response. MDPI 2022-11-13 /pmc/articles/PMC9692975/ /pubmed/36422017 http://dx.doi.org/10.3390/jof8111196 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chang, Che-Kang Yang, Min-Chi Chen, Hsueh-Fen Liao, Yi-Ling Lan, Chung-Yu The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title | The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title_full | The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title_fullStr | The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title_full_unstemmed | The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title_short | The Role of Sfp1 in Candida albicans Cell Wall Maintenance |
title_sort | role of sfp1 in candida albicans cell wall maintenance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692975/ https://www.ncbi.nlm.nih.gov/pubmed/36422017 http://dx.doi.org/10.3390/jof8111196 |
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