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Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia

Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the systemic blood metabolome are not fully understood. The aim o...

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Autores principales: More, Tushar H., Mozafari, Bahareh, Märtens, Andre, Herr, Christian, Lepper, Philipp M., Danziger, Guy, Volk, Thomas, Hoersch, Sabrina, Krawczyk, Marcin, Guenther, Katharina, Hiller, Karsten, Bals, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693035/
https://www.ncbi.nlm.nih.gov/pubmed/36355140
http://dx.doi.org/10.3390/metabo12111058
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author More, Tushar H.
Mozafari, Bahareh
Märtens, Andre
Herr, Christian
Lepper, Philipp M.
Danziger, Guy
Volk, Thomas
Hoersch, Sabrina
Krawczyk, Marcin
Guenther, Katharina
Hiller, Karsten
Bals, Robert
author_facet More, Tushar H.
Mozafari, Bahareh
Märtens, Andre
Herr, Christian
Lepper, Philipp M.
Danziger, Guy
Volk, Thomas
Hoersch, Sabrina
Krawczyk, Marcin
Guenther, Katharina
Hiller, Karsten
Bals, Robert
author_sort More, Tushar H.
collection PubMed
description Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the systemic blood metabolome are not fully understood. The aim of this study was to compare the blood metabolome of both diseases and we hypothesize that plasma metabolomics may help to identify the systemic effects of these diseases. Therefore, we profiled the plasma metabolome of 43 cases of COVID-19 pneumonia, 23 cases of non-COVID-19 pneumonia, and 26 controls using a non-targeted approach. Metabolic alterations differentiating the three groups were detected, with specific metabolic changes distinguishing the two types of pneumonia groups. A comparison of venous and arterial blood plasma samples from the same subjects revealed the distinct metabolic effects of pulmonary pneumonia. In addition, a machine learning signature of four metabolites was predictive of the disease outcome of COVID-19 subjects with an area under the curve (AUC) of 86 ± 10%. Overall, the results of this study uncover systemic metabolic changes that could be linked to the etiology of COVID-19 pneumonia and non-COVID-19 pneumonia.
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spelling pubmed-96930352022-11-26 Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia More, Tushar H. Mozafari, Bahareh Märtens, Andre Herr, Christian Lepper, Philipp M. Danziger, Guy Volk, Thomas Hoersch, Sabrina Krawczyk, Marcin Guenther, Katharina Hiller, Karsten Bals, Robert Metabolites Article Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the systemic blood metabolome are not fully understood. The aim of this study was to compare the blood metabolome of both diseases and we hypothesize that plasma metabolomics may help to identify the systemic effects of these diseases. Therefore, we profiled the plasma metabolome of 43 cases of COVID-19 pneumonia, 23 cases of non-COVID-19 pneumonia, and 26 controls using a non-targeted approach. Metabolic alterations differentiating the three groups were detected, with specific metabolic changes distinguishing the two types of pneumonia groups. A comparison of venous and arterial blood plasma samples from the same subjects revealed the distinct metabolic effects of pulmonary pneumonia. In addition, a machine learning signature of four metabolites was predictive of the disease outcome of COVID-19 subjects with an area under the curve (AUC) of 86 ± 10%. Overall, the results of this study uncover systemic metabolic changes that could be linked to the etiology of COVID-19 pneumonia and non-COVID-19 pneumonia. MDPI 2022-11-02 /pmc/articles/PMC9693035/ /pubmed/36355140 http://dx.doi.org/10.3390/metabo12111058 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
More, Tushar H.
Mozafari, Bahareh
Märtens, Andre
Herr, Christian
Lepper, Philipp M.
Danziger, Guy
Volk, Thomas
Hoersch, Sabrina
Krawczyk, Marcin
Guenther, Katharina
Hiller, Karsten
Bals, Robert
Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title_full Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title_fullStr Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title_full_unstemmed Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title_short Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
title_sort plasma metabolome alterations discriminate between covid-19 and non-covid-19 pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693035/
https://www.ncbi.nlm.nih.gov/pubmed/36355140
http://dx.doi.org/10.3390/metabo12111058
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