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The Discovery of Potential SARS-CoV-2 Natural Inhibitors among 4924 African Metabolites Targeting the Papain-like Protease: A Multi-Phase In Silico Approach

Four compounds, hippacine, 4,2′-dihydroxy-4′-methoxychalcone, 2′,5′-dihydroxy-4-methoxychalcone, and wighteone, were selected from 4924 African natural metabolites as potential inhibitors against SARS-CoV-2 papain-like protease (PLpro, PDB ID: 3E9S). A multi-phased in silico approach was employed to...

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Detalles Bibliográficos
Autores principales:	Elkaeed, Eslam B., Khalifa, Mohamed M., Alsfouk, Bshra A., Alsfouk, Aisha A., El-Attar, Abdul-Aziz M. M., Eissa, Ibrahim H., Metwaly, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693093/ https://www.ncbi.nlm.nih.gov/pubmed/36422263 http://dx.doi.org/10.3390/metabo12111122

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