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Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis

The interaction between the series of berberine derivatives 1–5 (NAX071, NAX120, NAX075, NAX077 and NAX079) and human telomeric G-quadruplexes (G4), which are able to inhibit the Telomerase enzyme’s activity in malignant cells, was investigated. The derivatives bear a pyridine moiety connected by a...

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Detalles Bibliográficos
Autores principales:	Bazzicalupi, Carla, Bonardi, Alessandro, Biver, Tarita, Ferraroni, Marta, Papi, Francesco, Savastano, Matteo, Lombardi, Paolo, Gratteri, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693123/ https://www.ncbi.nlm.nih.gov/pubmed/36430540 http://dx.doi.org/10.3390/ijms232214061

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