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Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers

Polybrominated diphenyl ethers (PBDE) are a group of flame retardants used in a variety of artificial materials. Despite being phased out in most industrial countries, they remain in the environment and human tissues due to their persistence, lipophilicity, and bioaccumulation. Populational and expe...

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Autores principales: Arowolo, Olatunbosun, Pilsner, J. Richard, Sergeyev, Oleg, Suvorov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693139/
https://www.ncbi.nlm.nih.gov/pubmed/36430706
http://dx.doi.org/10.3390/ijms232214229
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author Arowolo, Olatunbosun
Pilsner, J. Richard
Sergeyev, Oleg
Suvorov, Alexander
author_facet Arowolo, Olatunbosun
Pilsner, J. Richard
Sergeyev, Oleg
Suvorov, Alexander
author_sort Arowolo, Olatunbosun
collection PubMed
description Polybrominated diphenyl ethers (PBDE) are a group of flame retardants used in a variety of artificial materials. Despite being phased out in most industrial countries, they remain in the environment and human tissues due to their persistence, lipophilicity, and bioaccumulation. Populational and experimental studies demonstrate the male reproductive toxicity of PBDEs including increased incidence of genital malformations (hypospadias and cryptorchidism), altered weight of testes and other reproductive tissues, altered testes histology and transcriptome, decreased sperm production and sperm quality, altered epigenetic regulation of developmental genes in spermatozoa, and altered secretion of reproductive hormones. A broad range of mechanistic hypotheses of PBDE reproductive toxicity has been suggested. Among these hypotheses, oxidative stress, the disruption of estrogenic signaling, and mitochondria disruption are affected by PBDE concentrations much higher than concentrations found in human tissues, making them unlikely links between exposures and adverse reproductive outcomes in the general population. Robust evidence suggests that at environmentally relevant doses, PBDEs and their metabolites may affect male reproductive health via mechanisms including AR antagonism and the disruption of a complex network of metabolic signaling.
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spelling pubmed-96931392022-11-26 Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers Arowolo, Olatunbosun Pilsner, J. Richard Sergeyev, Oleg Suvorov, Alexander Int J Mol Sci Review Polybrominated diphenyl ethers (PBDE) are a group of flame retardants used in a variety of artificial materials. Despite being phased out in most industrial countries, they remain in the environment and human tissues due to their persistence, lipophilicity, and bioaccumulation. Populational and experimental studies demonstrate the male reproductive toxicity of PBDEs including increased incidence of genital malformations (hypospadias and cryptorchidism), altered weight of testes and other reproductive tissues, altered testes histology and transcriptome, decreased sperm production and sperm quality, altered epigenetic regulation of developmental genes in spermatozoa, and altered secretion of reproductive hormones. A broad range of mechanistic hypotheses of PBDE reproductive toxicity has been suggested. Among these hypotheses, oxidative stress, the disruption of estrogenic signaling, and mitochondria disruption are affected by PBDE concentrations much higher than concentrations found in human tissues, making them unlikely links between exposures and adverse reproductive outcomes in the general population. Robust evidence suggests that at environmentally relevant doses, PBDEs and their metabolites may affect male reproductive health via mechanisms including AR antagonism and the disruption of a complex network of metabolic signaling. MDPI 2022-11-17 /pmc/articles/PMC9693139/ /pubmed/36430706 http://dx.doi.org/10.3390/ijms232214229 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Arowolo, Olatunbosun
Pilsner, J. Richard
Sergeyev, Oleg
Suvorov, Alexander
Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title_full Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title_fullStr Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title_full_unstemmed Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title_short Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers
title_sort mechanisms of male reproductive toxicity of polybrominated diphenyl ethers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693139/
https://www.ncbi.nlm.nih.gov/pubmed/36430706
http://dx.doi.org/10.3390/ijms232214229
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