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Quantifying Deaths from Aspergillosis in HIV Positive People

Aspergillus spp. are ubiquitous and cause severe infections in immunocompromised patients. Less is known about its incidence and prognosis in patients with HIV/AIDS. We reviewed the mortality of invasive aspergillosis in HIV/AIDS patients. Pubmed, Embase and Medline databases were used to search for...

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Autores principales: Denning, David W., Morgan, Ellen Frances
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693143/
https://www.ncbi.nlm.nih.gov/pubmed/36354898
http://dx.doi.org/10.3390/jof8111131
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author Denning, David W.
Morgan, Ellen Frances
author_facet Denning, David W.
Morgan, Ellen Frances
author_sort Denning, David W.
collection PubMed
description Aspergillus spp. are ubiquitous and cause severe infections in immunocompromised patients. Less is known about its incidence and prognosis in patients with HIV/AIDS. We reviewed the mortality of invasive aspergillosis in HIV/AIDS patients. Pubmed, Embase and Medline databases were used to search for articles. Studies were excluded if they contained other aspergillosis risk factors, no original or patient survival data or were not in English. From 747 articles published, 54 studies and case reports were identified following reading, published between 1985 and 2021, with 54% papers prior to 2000 reporting 853 patients from 16 countries, none from Africa. 707 (83%) patients died with an average time from diagnosis to death of 77.5 days. Postmortem diagnosis was seen in 21% of deaths recorded. A national series from France of 242 cases of invasive aspergillosis diagnosed in life recorded a 3 month mortality of 68% pre-ART, falling to 31% after introduction of ART and voriconazole. CD4 count was recorded in 39 studies and ranged from 2 to >1000 cells/mm(3); only 8 patients (1.8%) had a CD4 > 100 cells/mm(3). Aspergillosis occurs in patients with HIV/AIDS and associated with high mortality but its slow progression should allow diagnosis and treatment with improved outcome.
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spelling pubmed-96931432022-11-26 Quantifying Deaths from Aspergillosis in HIV Positive People Denning, David W. Morgan, Ellen Frances J Fungi (Basel) Review Aspergillus spp. are ubiquitous and cause severe infections in immunocompromised patients. Less is known about its incidence and prognosis in patients with HIV/AIDS. We reviewed the mortality of invasive aspergillosis in HIV/AIDS patients. Pubmed, Embase and Medline databases were used to search for articles. Studies were excluded if they contained other aspergillosis risk factors, no original or patient survival data or were not in English. From 747 articles published, 54 studies and case reports were identified following reading, published between 1985 and 2021, with 54% papers prior to 2000 reporting 853 patients from 16 countries, none from Africa. 707 (83%) patients died with an average time from diagnosis to death of 77.5 days. Postmortem diagnosis was seen in 21% of deaths recorded. A national series from France of 242 cases of invasive aspergillosis diagnosed in life recorded a 3 month mortality of 68% pre-ART, falling to 31% after introduction of ART and voriconazole. CD4 count was recorded in 39 studies and ranged from 2 to >1000 cells/mm(3); only 8 patients (1.8%) had a CD4 > 100 cells/mm(3). Aspergillosis occurs in patients with HIV/AIDS and associated with high mortality but its slow progression should allow diagnosis and treatment with improved outcome. MDPI 2022-10-27 /pmc/articles/PMC9693143/ /pubmed/36354898 http://dx.doi.org/10.3390/jof8111131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Denning, David W.
Morgan, Ellen Frances
Quantifying Deaths from Aspergillosis in HIV Positive People
title Quantifying Deaths from Aspergillosis in HIV Positive People
title_full Quantifying Deaths from Aspergillosis in HIV Positive People
title_fullStr Quantifying Deaths from Aspergillosis in HIV Positive People
title_full_unstemmed Quantifying Deaths from Aspergillosis in HIV Positive People
title_short Quantifying Deaths from Aspergillosis in HIV Positive People
title_sort quantifying deaths from aspergillosis in hiv positive people
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693143/
https://www.ncbi.nlm.nih.gov/pubmed/36354898
http://dx.doi.org/10.3390/jof8111131
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