Cargando…

Seasonality of Deaths Due to Heart Diseases among Cancer Patients

Background and Objectives: Cancer patients are at increased short- and long-term risk of cardiac toxicity and mortality. It is well-known that cardiac morbidity and mortality follows a seasonal pattern. Here we address the question of whether heart disease-related fatalities among cancer patients al...

Descripción completa

Detalles Bibliográficos
Autores principales: Shivarov, Velizar, Shivarov, Hristo, Yordanov, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693160/
https://www.ncbi.nlm.nih.gov/pubmed/36422190
http://dx.doi.org/10.3390/medicina58111651
_version_ 1784837465748537344
author Shivarov, Velizar
Shivarov, Hristo
Yordanov, Angel
author_facet Shivarov, Velizar
Shivarov, Hristo
Yordanov, Angel
author_sort Shivarov, Velizar
collection PubMed
description Background and Objectives: Cancer patients are at increased short- and long-term risk of cardiac toxicity and mortality. It is well-known that cardiac morbidity and mortality follows a seasonal pattern. Here we address the question of whether heart disease-related fatalities among cancer patients also follow a seasonal pattern. Materials and Methods: We performed a retrospective analysis of seasonality of deaths due to heart diseases (n = 503,243) in patients with newly diagnosed cancer reported during the period from 1975 to 2016 in the US’s largest cancer registry—the Surveillance, Epidemiology, and End Results (SEER) database. Seasonality was assessed through a classical cosinor model assuming a single annual peak. Results: We identified a significant seasonal peak in the first half of November. A peak with identical features was for all subgroups of patients defined based on demographic characteristics. This was also the case when analysis was performed on subgroups defined by the type of malignancy. Only patients with acute leukemias, pancreatic cancer and nervous system malignancies did not have a seasonal pattern in heart disease-related fatalities. Conclusion: the rate of heart disease-related fatalities after cancer diagnosis follows a seasonal pattern similar to that observed for the general population, albeit with an earlier peak in November. This suggests that close monitoring of the cardiovascular system in cancer survivors must be particularly active from late autumn and during the entire winter period.
format Online
Article
Text
id pubmed-9693160
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96931602022-11-26 Seasonality of Deaths Due to Heart Diseases among Cancer Patients Shivarov, Velizar Shivarov, Hristo Yordanov, Angel Medicina (Kaunas) Article Background and Objectives: Cancer patients are at increased short- and long-term risk of cardiac toxicity and mortality. It is well-known that cardiac morbidity and mortality follows a seasonal pattern. Here we address the question of whether heart disease-related fatalities among cancer patients also follow a seasonal pattern. Materials and Methods: We performed a retrospective analysis of seasonality of deaths due to heart diseases (n = 503,243) in patients with newly diagnosed cancer reported during the period from 1975 to 2016 in the US’s largest cancer registry—the Surveillance, Epidemiology, and End Results (SEER) database. Seasonality was assessed through a classical cosinor model assuming a single annual peak. Results: We identified a significant seasonal peak in the first half of November. A peak with identical features was for all subgroups of patients defined based on demographic characteristics. This was also the case when analysis was performed on subgroups defined by the type of malignancy. Only patients with acute leukemias, pancreatic cancer and nervous system malignancies did not have a seasonal pattern in heart disease-related fatalities. Conclusion: the rate of heart disease-related fatalities after cancer diagnosis follows a seasonal pattern similar to that observed for the general population, albeit with an earlier peak in November. This suggests that close monitoring of the cardiovascular system in cancer survivors must be particularly active from late autumn and during the entire winter period. MDPI 2022-11-15 /pmc/articles/PMC9693160/ /pubmed/36422190 http://dx.doi.org/10.3390/medicina58111651 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shivarov, Velizar
Shivarov, Hristo
Yordanov, Angel
Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title_full Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title_fullStr Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title_full_unstemmed Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title_short Seasonality of Deaths Due to Heart Diseases among Cancer Patients
title_sort seasonality of deaths due to heart diseases among cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693160/
https://www.ncbi.nlm.nih.gov/pubmed/36422190
http://dx.doi.org/10.3390/medicina58111651
work_keys_str_mv AT shivarovvelizar seasonalityofdeathsduetoheartdiseasesamongcancerpatients
AT shivarovhristo seasonalityofdeathsduetoheartdiseasesamongcancerpatients
AT yordanovangel seasonalityofdeathsduetoheartdiseasesamongcancerpatients