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Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component

Microbial infections represent a problem of great importance at the public health level, with a high rate of morbidity-mortality worldwide. However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against vari...

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Autores principales: Rincón-Cortés, Clara Andrea, Bayona-Rojas, Martín Alonso, Reyes-Montaño, Edgar Antonio, Vega-Castro, Nohora Angélica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693228/
https://www.ncbi.nlm.nih.gov/pubmed/36355990
http://dx.doi.org/10.3390/toxins14110740
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author Rincón-Cortés, Clara Andrea
Bayona-Rojas, Martín Alonso
Reyes-Montaño, Edgar Antonio
Vega-Castro, Nohora Angélica
author_facet Rincón-Cortés, Clara Andrea
Bayona-Rojas, Martín Alonso
Reyes-Montaño, Edgar Antonio
Vega-Castro, Nohora Angélica
author_sort Rincón-Cortés, Clara Andrea
collection PubMed
description Microbial infections represent a problem of great importance at the public health level, with a high rate of morbidity-mortality worldwide. However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against various antibiotic therapies. Resistance is caused by various molecular mechanisms of microorganisms, thus reducing their effectiveness. Consequently, there is a need to search for new opportunities through natural sources with antimicrobial activity. One alternative is using peptides present in different scorpion venoms, specifically from the Buthidae family. Different peptides with biological activity in microorganisms have been characterized as preventing their growth or inhibiting their replication. Therefore, they represent an alternative to be used in the design and development of new-generation antimicrobial drugs in different types of microorganisms, such as bacteria, fungi, viruses, and parasites. Essential aspects for its disclosure, as shown in this review, are the studies carried out on different types of peptides in scorpion venoms with activity against pathogenic microorganisms, highlighting their high therapeutic potential.
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spelling pubmed-96932282022-11-26 Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component Rincón-Cortés, Clara Andrea Bayona-Rojas, Martín Alonso Reyes-Montaño, Edgar Antonio Vega-Castro, Nohora Angélica Toxins (Basel) Review Microbial infections represent a problem of great importance at the public health level, with a high rate of morbidity-mortality worldwide. However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against various antibiotic therapies. Resistance is caused by various molecular mechanisms of microorganisms, thus reducing their effectiveness. Consequently, there is a need to search for new opportunities through natural sources with antimicrobial activity. One alternative is using peptides present in different scorpion venoms, specifically from the Buthidae family. Different peptides with biological activity in microorganisms have been characterized as preventing their growth or inhibiting their replication. Therefore, they represent an alternative to be used in the design and development of new-generation antimicrobial drugs in different types of microorganisms, such as bacteria, fungi, viruses, and parasites. Essential aspects for its disclosure, as shown in this review, are the studies carried out on different types of peptides in scorpion venoms with activity against pathogenic microorganisms, highlighting their high therapeutic potential. MDPI 2022-10-28 /pmc/articles/PMC9693228/ /pubmed/36355990 http://dx.doi.org/10.3390/toxins14110740 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rincón-Cortés, Clara Andrea
Bayona-Rojas, Martín Alonso
Reyes-Montaño, Edgar Antonio
Vega-Castro, Nohora Angélica
Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title_full Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title_fullStr Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title_full_unstemmed Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title_short Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component
title_sort antimicrobial activity developed by scorpion venoms and its peptide component
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693228/
https://www.ncbi.nlm.nih.gov/pubmed/36355990
http://dx.doi.org/10.3390/toxins14110740
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