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Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention

Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in...

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Autores principales: Kumric, Marko, Urlic, Hrvoje, Bilalic, Admira, Rezic-Muzinic, Nikolina, Mastelic, Angela, Markotic, Anita, Rusic, Doris, Borovac, Josip A., Duplancic, Darko, Luetic, Marina, Covic, Ivan, Ticinovic Kurir, Tina, Bozic, Josko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693248/
https://www.ncbi.nlm.nih.gov/pubmed/36421930
http://dx.doi.org/10.3390/jcdd9110395
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author Kumric, Marko
Urlic, Hrvoje
Bilalic, Admira
Rezic-Muzinic, Nikolina
Mastelic, Angela
Markotic, Anita
Rusic, Doris
Borovac, Josip A.
Duplancic, Darko
Luetic, Marina
Covic, Ivan
Ticinovic Kurir, Tina
Bozic, Josko
author_facet Kumric, Marko
Urlic, Hrvoje
Bilalic, Admira
Rezic-Muzinic, Nikolina
Mastelic, Angela
Markotic, Anita
Rusic, Doris
Borovac, Josip A.
Duplancic, Darko
Luetic, Marina
Covic, Ivan
Ticinovic Kurir, Tina
Bozic, Josko
author_sort Kumric, Marko
collection PubMed
description Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in NK cell education, may be involved in cardiac remodeling following coronary artery occlusion. In the present study, we aimed to explore the dynamic of DNAM-1+ monocytes and NK cells in peripheral blood in the early phase following reperfusion in patients with ST-elevation MI (STEMI). The study enrolled 49 patients older than 18 years of age diagnosed with STEMI, referred to primary percutaneous coronary intervention (pPCI). Blood samples were obtained at three distinct points (at admission, 3 h, and 24 h after pPCI) and analyzed using flow cytometry. The number of circulating DNAM-1+ monocytes (CD16++ and CD14++) and CD56dimCD16++NK cells was significantly reduced 3 h after pPCI and subsequently returned to initial levels 24 h after procedure (p = 0.003, p < 0.001, and p = 0.002, respectively). Notably, such dynamic was dependent on age of patients. A positive correlation between high sensitivity troponin I levels and number of CD16++DNAM-1+ monocytes in peripheral blood 3 h after pPCI was observed (r = 0.431, p = 0.003). In conclusion, in the present study we delineated the post-reperfusion dynamic of DNAM-1-expresing leukocytes. Additionally, we demonstrated that the number of CD16++ DNAM-1+ monocytes correlate with the extent of myocardial injury.
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spelling pubmed-96932482022-11-26 Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention Kumric, Marko Urlic, Hrvoje Bilalic, Admira Rezic-Muzinic, Nikolina Mastelic, Angela Markotic, Anita Rusic, Doris Borovac, Josip A. Duplancic, Darko Luetic, Marina Covic, Ivan Ticinovic Kurir, Tina Bozic, Josko J Cardiovasc Dev Dis Article Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in NK cell education, may be involved in cardiac remodeling following coronary artery occlusion. In the present study, we aimed to explore the dynamic of DNAM-1+ monocytes and NK cells in peripheral blood in the early phase following reperfusion in patients with ST-elevation MI (STEMI). The study enrolled 49 patients older than 18 years of age diagnosed with STEMI, referred to primary percutaneous coronary intervention (pPCI). Blood samples were obtained at three distinct points (at admission, 3 h, and 24 h after pPCI) and analyzed using flow cytometry. The number of circulating DNAM-1+ monocytes (CD16++ and CD14++) and CD56dimCD16++NK cells was significantly reduced 3 h after pPCI and subsequently returned to initial levels 24 h after procedure (p = 0.003, p < 0.001, and p = 0.002, respectively). Notably, such dynamic was dependent on age of patients. A positive correlation between high sensitivity troponin I levels and number of CD16++DNAM-1+ monocytes in peripheral blood 3 h after pPCI was observed (r = 0.431, p = 0.003). In conclusion, in the present study we delineated the post-reperfusion dynamic of DNAM-1-expresing leukocytes. Additionally, we demonstrated that the number of CD16++ DNAM-1+ monocytes correlate with the extent of myocardial injury. MDPI 2022-11-15 /pmc/articles/PMC9693248/ /pubmed/36421930 http://dx.doi.org/10.3390/jcdd9110395 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kumric, Marko
Urlic, Hrvoje
Bilalic, Admira
Rezic-Muzinic, Nikolina
Mastelic, Angela
Markotic, Anita
Rusic, Doris
Borovac, Josip A.
Duplancic, Darko
Luetic, Marina
Covic, Ivan
Ticinovic Kurir, Tina
Bozic, Josko
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title_full Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title_fullStr Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title_full_unstemmed Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title_short Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
title_sort dynamic of circulating dnam-1+ monocytes and nk cells in patients with stemi following primary percutaneous coronary intervention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693248/
https://www.ncbi.nlm.nih.gov/pubmed/36421930
http://dx.doi.org/10.3390/jcdd9110395
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