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Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders

Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not o...

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Autores principales: Ovchinnikova, Leyla A., Zalevsky, Arthur O., Lomakin, Yakov A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693249/
https://www.ncbi.nlm.nih.gov/pubmed/36431078
http://dx.doi.org/10.3390/life12111943
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author Ovchinnikova, Leyla A.
Zalevsky, Arthur O.
Lomakin, Yakov A.
author_facet Ovchinnikova, Leyla A.
Zalevsky, Arthur O.
Lomakin, Yakov A.
author_sort Ovchinnikova, Leyla A.
collection PubMed
description Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not only for various EV-loaded molecules to be delivered to the brain tissues but also for the CNS-to-periphery transmission of these molecules. Since neural EVs transfer proteins and RNAs are both responsible for functional intercellular communication and involved in the pathogenesis of neurodegenerative diseases, they represent attractive diagnostic and therapeutic targets. Here, we discuss EVs’ role in maintaining the living organisms’ function and describe deviations in EVs’ structure and malfunctioning during various neurodegenerative diseases.
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spelling pubmed-96932492022-11-26 Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders Ovchinnikova, Leyla A. Zalevsky, Arthur O. Lomakin, Yakov A. Life (Basel) Review Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not only for various EV-loaded molecules to be delivered to the brain tissues but also for the CNS-to-periphery transmission of these molecules. Since neural EVs transfer proteins and RNAs are both responsible for functional intercellular communication and involved in the pathogenesis of neurodegenerative diseases, they represent attractive diagnostic and therapeutic targets. Here, we discuss EVs’ role in maintaining the living organisms’ function and describe deviations in EVs’ structure and malfunctioning during various neurodegenerative diseases. MDPI 2022-11-21 /pmc/articles/PMC9693249/ /pubmed/36431078 http://dx.doi.org/10.3390/life12111943 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ovchinnikova, Leyla A.
Zalevsky, Arthur O.
Lomakin, Yakov A.
Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title_full Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title_fullStr Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title_full_unstemmed Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title_short Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
title_sort extracellular vesicles in chronic demyelinating diseases: prospects in treatment and diagnosis of autoimmune neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693249/
https://www.ncbi.nlm.nih.gov/pubmed/36431078
http://dx.doi.org/10.3390/life12111943
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