Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon(®) VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel strategy for...

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Detalles Bibliográficos
Autores principales: Triboandas, Hetvi, Pitt, Kendal, Bezerra, Mariana, Ach-Hubert, Delphine, Schlindwein, Walkiria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693276/
https://www.ncbi.nlm.nih.gov/pubmed/36365216
http://dx.doi.org/10.3390/pharmaceutics14112398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693276/
https://www.ncbi.nlm.nih.gov/pubmed/36365216
http://dx.doi.org/10.3390/pharmaceutics14112398

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