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Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools
BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon(®) VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel strategy for...
Autores principales: | Triboandas, Hetvi, Pitt, Kendal, Bezerra, Mariana, Ach-Hubert, Delphine, Schlindwein, Walkiria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693276/ https://www.ncbi.nlm.nih.gov/pubmed/36365216 http://dx.doi.org/10.3390/pharmaceutics14112398 |
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