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Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature

Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been report...

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Autores principales: Brogna, Claudia, Brogna, Barbara, De Biase, Margherita, Sini, Francesca, Mirra, Federica, Moro, Marianna, Romeo, Domenico M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693289/
https://www.ncbi.nlm.nih.gov/pubmed/36431302
http://dx.doi.org/10.3390/jcm11226827
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author Brogna, Claudia
Brogna, Barbara
De Biase, Margherita
Sini, Francesca
Mirra, Federica
Moro, Marianna
Romeo, Domenico M.
author_facet Brogna, Claudia
Brogna, Barbara
De Biase, Margherita
Sini, Francesca
Mirra, Federica
Moro, Marianna
Romeo, Domenico M.
author_sort Brogna, Claudia
collection PubMed
description Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been reported in children presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from asymptomatic status to severe disease sustained by an immune-mediated inflammatory response. SARS-CoV-2 has been associated with severe neurological diseases including seizures and encephalitis in both adults and children. However, there are still few reports regarding the possible relation between SARS-CoV-2 infection of mothers during pregnancy and the neurologic outcome of the newborns. We described the case of a newborn diagnosed with a perinatal stroke, born at 35 weeks of gestation from a mother presenting with SARS- CoV-2 infection during the last months of pregnancy. We also added a brief review of the literature with similar cases. Close monitoring and early intervention in young children born to infected mothers would be highly recommended for the potential neurodevelopmental risk.
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spelling pubmed-96932892022-11-26 Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature Brogna, Claudia Brogna, Barbara De Biase, Margherita Sini, Francesca Mirra, Federica Moro, Marianna Romeo, Domenico M. J Clin Med Communication Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been reported in children presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from asymptomatic status to severe disease sustained by an immune-mediated inflammatory response. SARS-CoV-2 has been associated with severe neurological diseases including seizures and encephalitis in both adults and children. However, there are still few reports regarding the possible relation between SARS-CoV-2 infection of mothers during pregnancy and the neurologic outcome of the newborns. We described the case of a newborn diagnosed with a perinatal stroke, born at 35 weeks of gestation from a mother presenting with SARS- CoV-2 infection during the last months of pregnancy. We also added a brief review of the literature with similar cases. Close monitoring and early intervention in young children born to infected mothers would be highly recommended for the potential neurodevelopmental risk. MDPI 2022-11-18 /pmc/articles/PMC9693289/ /pubmed/36431302 http://dx.doi.org/10.3390/jcm11226827 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Brogna, Claudia
Brogna, Barbara
De Biase, Margherita
Sini, Francesca
Mirra, Federica
Moro, Marianna
Romeo, Domenico M.
Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title_full Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title_fullStr Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title_full_unstemmed Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title_short Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
title_sort perinatal cerebral ischemic lesion and sars-cov-2 infection during pregnancy: a case report and a review of the literature
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693289/
https://www.ncbi.nlm.nih.gov/pubmed/36431302
http://dx.doi.org/10.3390/jcm11226827
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