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Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives

Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...

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Autores principales: Silva-Aguiar, Rodrigo P., Teixeira, Douglas E., Peres, Rodrigo A. S., Peruchetti, Diogo B., Gomes, Carlos P., Schmaier, Alvin H., Rocco, Patricia R. M., Pinheiro, Ana Acacia S., Caruso-Neves, Celso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693299/
https://www.ncbi.nlm.nih.gov/pubmed/36430671
http://dx.doi.org/10.3390/ijms232214193
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author Silva-Aguiar, Rodrigo P.
Teixeira, Douglas E.
Peres, Rodrigo A. S.
Peruchetti, Diogo B.
Gomes, Carlos P.
Schmaier, Alvin H.
Rocco, Patricia R. M.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
author_facet Silva-Aguiar, Rodrigo P.
Teixeira, Douglas E.
Peres, Rodrigo A. S.
Peruchetti, Diogo B.
Gomes, Carlos P.
Schmaier, Alvin H.
Rocco, Patricia R. M.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
author_sort Silva-Aguiar, Rodrigo P.
collection PubMed
description Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to the development of acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with COVID-19. However, the detection of kidney damage in patients with COVID-19 may not occur until an advanced stage based on the current clinical blood and urinary examinations. Some studies have pointed out the development of subclinical acute kidney injury (subAKI) syndrome with COVID-19. This syndrome is characterized by significant tubule interstitial injury without changes in the estimated glomerular filtration rate. Despite the complexity of the mechanism(s) underlying the development of subAKI, the involvement of changes in the protein endocytosis machinery in proximal tubule (PT) epithelial cells (PTECs) has been proposed. This paper focuses on the data relating to subAKI and COVID-19 and the role of PTECs and their protein endocytosis machinery in its pathogenesis.
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spelling pubmed-96932992022-11-26 Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives Silva-Aguiar, Rodrigo P. Teixeira, Douglas E. Peres, Rodrigo A. S. Peruchetti, Diogo B. Gomes, Carlos P. Schmaier, Alvin H. Rocco, Patricia R. M. Pinheiro, Ana Acacia S. Caruso-Neves, Celso Int J Mol Sci Review Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to the development of acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with COVID-19. However, the detection of kidney damage in patients with COVID-19 may not occur until an advanced stage based on the current clinical blood and urinary examinations. Some studies have pointed out the development of subclinical acute kidney injury (subAKI) syndrome with COVID-19. This syndrome is characterized by significant tubule interstitial injury without changes in the estimated glomerular filtration rate. Despite the complexity of the mechanism(s) underlying the development of subAKI, the involvement of changes in the protein endocytosis machinery in proximal tubule (PT) epithelial cells (PTECs) has been proposed. This paper focuses on the data relating to subAKI and COVID-19 and the role of PTECs and their protein endocytosis machinery in its pathogenesis. MDPI 2022-11-17 /pmc/articles/PMC9693299/ /pubmed/36430671 http://dx.doi.org/10.3390/ijms232214193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Silva-Aguiar, Rodrigo P.
Teixeira, Douglas E.
Peres, Rodrigo A. S.
Peruchetti, Diogo B.
Gomes, Carlos P.
Schmaier, Alvin H.
Rocco, Patricia R. M.
Pinheiro, Ana Acacia S.
Caruso-Neves, Celso
Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title_full Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title_fullStr Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title_full_unstemmed Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title_short Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
title_sort subclinical acute kidney injury in covid-19: possible mechanisms and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693299/
https://www.ncbi.nlm.nih.gov/pubmed/36430671
http://dx.doi.org/10.3390/ijms232214193
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