Cargando…
Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives
Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693299/ https://www.ncbi.nlm.nih.gov/pubmed/36430671 http://dx.doi.org/10.3390/ijms232214193 |
_version_ | 1784837505036582912 |
---|---|
author | Silva-Aguiar, Rodrigo P. Teixeira, Douglas E. Peres, Rodrigo A. S. Peruchetti, Diogo B. Gomes, Carlos P. Schmaier, Alvin H. Rocco, Patricia R. M. Pinheiro, Ana Acacia S. Caruso-Neves, Celso |
author_facet | Silva-Aguiar, Rodrigo P. Teixeira, Douglas E. Peres, Rodrigo A. S. Peruchetti, Diogo B. Gomes, Carlos P. Schmaier, Alvin H. Rocco, Patricia R. M. Pinheiro, Ana Acacia S. Caruso-Neves, Celso |
author_sort | Silva-Aguiar, Rodrigo P. |
collection | PubMed |
description | Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to the development of acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with COVID-19. However, the detection of kidney damage in patients with COVID-19 may not occur until an advanced stage based on the current clinical blood and urinary examinations. Some studies have pointed out the development of subclinical acute kidney injury (subAKI) syndrome with COVID-19. This syndrome is characterized by significant tubule interstitial injury without changes in the estimated glomerular filtration rate. Despite the complexity of the mechanism(s) underlying the development of subAKI, the involvement of changes in the protein endocytosis machinery in proximal tubule (PT) epithelial cells (PTECs) has been proposed. This paper focuses on the data relating to subAKI and COVID-19 and the role of PTECs and their protein endocytosis machinery in its pathogenesis. |
format | Online Article Text |
id | pubmed-9693299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96932992022-11-26 Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives Silva-Aguiar, Rodrigo P. Teixeira, Douglas E. Peres, Rodrigo A. S. Peruchetti, Diogo B. Gomes, Carlos P. Schmaier, Alvin H. Rocco, Patricia R. M. Pinheiro, Ana Acacia S. Caruso-Neves, Celso Int J Mol Sci Review Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to the development of acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with COVID-19. However, the detection of kidney damage in patients with COVID-19 may not occur until an advanced stage based on the current clinical blood and urinary examinations. Some studies have pointed out the development of subclinical acute kidney injury (subAKI) syndrome with COVID-19. This syndrome is characterized by significant tubule interstitial injury without changes in the estimated glomerular filtration rate. Despite the complexity of the mechanism(s) underlying the development of subAKI, the involvement of changes in the protein endocytosis machinery in proximal tubule (PT) epithelial cells (PTECs) has been proposed. This paper focuses on the data relating to subAKI and COVID-19 and the role of PTECs and their protein endocytosis machinery in its pathogenesis. MDPI 2022-11-17 /pmc/articles/PMC9693299/ /pubmed/36430671 http://dx.doi.org/10.3390/ijms232214193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silva-Aguiar, Rodrigo P. Teixeira, Douglas E. Peres, Rodrigo A. S. Peruchetti, Diogo B. Gomes, Carlos P. Schmaier, Alvin H. Rocco, Patricia R. M. Pinheiro, Ana Acacia S. Caruso-Neves, Celso Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title | Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title_full | Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title_fullStr | Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title_full_unstemmed | Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title_short | Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives |
title_sort | subclinical acute kidney injury in covid-19: possible mechanisms and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693299/ https://www.ncbi.nlm.nih.gov/pubmed/36430671 http://dx.doi.org/10.3390/ijms232214193 |
work_keys_str_mv | AT silvaaguiarrodrigop subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT teixeiradouglase subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT peresrodrigoas subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT peruchettidiogob subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT gomescarlosp subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT schmaieralvinh subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT roccopatriciarm subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT pinheiroanaacacias subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives AT carusonevescelso subclinicalacutekidneyinjuryincovid19possiblemechanismsandfutureperspectives |