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Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study

In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 ma...

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Autores principales: Li, Yufen, Guo, Tong, Zhong, Jiayi, Fang, Chuanjun, Xiong, Husheng, Hu, Zengyun, Zhu, Yajuan, Tan, Jinlin, Liu, Shuang, Jing, Qinlong, Zhang, Dingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693306/
https://www.ncbi.nlm.nih.gov/pubmed/36366363
http://dx.doi.org/10.3390/vaccines10111855
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author Li, Yufen
Guo, Tong
Zhong, Jiayi
Fang, Chuanjun
Xiong, Husheng
Hu, Zengyun
Zhu, Yajuan
Tan, Jinlin
Liu, Shuang
Jing, Qinlong
Zhang, Dingmei
author_facet Li, Yufen
Guo, Tong
Zhong, Jiayi
Fang, Chuanjun
Xiong, Husheng
Hu, Zengyun
Zhu, Yajuan
Tan, Jinlin
Liu, Shuang
Jing, Qinlong
Zhang, Dingmei
author_sort Li, Yufen
collection PubMed
description In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 matched case–control sample was established, finally including n = 242 for the case group and n = 968 for the control group. The results indicated that among the participants who received three vaccine doses, those with an interval of more than 300 days between the receipt of the first vaccine dose and infection (or the first contact with a confirmed case) were less likely to be infected with SARS-CoV-2 than those with an interval of less than 300 days (OR = 0.67, 95% CI = 0.46–0.99). After age-stratified analysis, among participants aged 18–40 years who received two doses of vaccine, those who received the second dose more than 30 days after the first dose were less likely to be infected with SARS-CoV-2 (OR = 0.53, 95% CI = 0.30–0.96). Our findings suggest that we need to extend the interval between the first dose and the second dose and further explore the optimal interval between the first and second and between the second and third doses in order to improve vaccine efficacy.
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spelling pubmed-96933062022-11-26 Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study Li, Yufen Guo, Tong Zhong, Jiayi Fang, Chuanjun Xiong, Husheng Hu, Zengyun Zhu, Yajuan Tan, Jinlin Liu, Shuang Jing, Qinlong Zhang, Dingmei Vaccines (Basel) Article In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 matched case–control sample was established, finally including n = 242 for the case group and n = 968 for the control group. The results indicated that among the participants who received three vaccine doses, those with an interval of more than 300 days between the receipt of the first vaccine dose and infection (or the first contact with a confirmed case) were less likely to be infected with SARS-CoV-2 than those with an interval of less than 300 days (OR = 0.67, 95% CI = 0.46–0.99). After age-stratified analysis, among participants aged 18–40 years who received two doses of vaccine, those who received the second dose more than 30 days after the first dose were less likely to be infected with SARS-CoV-2 (OR = 0.53, 95% CI = 0.30–0.96). Our findings suggest that we need to extend the interval between the first dose and the second dose and further explore the optimal interval between the first and second and between the second and third doses in order to improve vaccine efficacy. MDPI 2022-11-01 /pmc/articles/PMC9693306/ /pubmed/36366363 http://dx.doi.org/10.3390/vaccines10111855 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yufen
Guo, Tong
Zhong, Jiayi
Fang, Chuanjun
Xiong, Husheng
Hu, Zengyun
Zhu, Yajuan
Tan, Jinlin
Liu, Shuang
Jing, Qinlong
Zhang, Dingmei
Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title_full Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title_fullStr Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title_full_unstemmed Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title_short Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
title_sort effect of vaccination time intervals on sars-cov-2 omicron variant strain infection in guangzhou: a real-world matched case–control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693306/
https://www.ncbi.nlm.nih.gov/pubmed/36366363
http://dx.doi.org/10.3390/vaccines10111855
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