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Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study
In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 ma...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693306/ https://www.ncbi.nlm.nih.gov/pubmed/36366363 http://dx.doi.org/10.3390/vaccines10111855 |
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author | Li, Yufen Guo, Tong Zhong, Jiayi Fang, Chuanjun Xiong, Husheng Hu, Zengyun Zhu, Yajuan Tan, Jinlin Liu, Shuang Jing, Qinlong Zhang, Dingmei |
author_facet | Li, Yufen Guo, Tong Zhong, Jiayi Fang, Chuanjun Xiong, Husheng Hu, Zengyun Zhu, Yajuan Tan, Jinlin Liu, Shuang Jing, Qinlong Zhang, Dingmei |
author_sort | Li, Yufen |
collection | PubMed |
description | In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 matched case–control sample was established, finally including n = 242 for the case group and n = 968 for the control group. The results indicated that among the participants who received three vaccine doses, those with an interval of more than 300 days between the receipt of the first vaccine dose and infection (or the first contact with a confirmed case) were less likely to be infected with SARS-CoV-2 than those with an interval of less than 300 days (OR = 0.67, 95% CI = 0.46–0.99). After age-stratified analysis, among participants aged 18–40 years who received two doses of vaccine, those who received the second dose more than 30 days after the first dose were less likely to be infected with SARS-CoV-2 (OR = 0.53, 95% CI = 0.30–0.96). Our findings suggest that we need to extend the interval between the first dose and the second dose and further explore the optimal interval between the first and second and between the second and third doses in order to improve vaccine efficacy. |
format | Online Article Text |
id | pubmed-9693306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96933062022-11-26 Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study Li, Yufen Guo, Tong Zhong, Jiayi Fang, Chuanjun Xiong, Husheng Hu, Zengyun Zhu, Yajuan Tan, Jinlin Liu, Shuang Jing, Qinlong Zhang, Dingmei Vaccines (Basel) Article In April 2022, a COVID-19 outbreak caused by the Omicron variant emerged in Guangzhou. A case–control study was conducted to explore the relationship between vaccination intervals and SARS-CoV-2 infection in the real world. According to the vaccination dose and age information of the cases, a 1:4 matched case–control sample was established, finally including n = 242 for the case group and n = 968 for the control group. The results indicated that among the participants who received three vaccine doses, those with an interval of more than 300 days between the receipt of the first vaccine dose and infection (or the first contact with a confirmed case) were less likely to be infected with SARS-CoV-2 than those with an interval of less than 300 days (OR = 0.67, 95% CI = 0.46–0.99). After age-stratified analysis, among participants aged 18–40 years who received two doses of vaccine, those who received the second dose more than 30 days after the first dose were less likely to be infected with SARS-CoV-2 (OR = 0.53, 95% CI = 0.30–0.96). Our findings suggest that we need to extend the interval between the first dose and the second dose and further explore the optimal interval between the first and second and between the second and third doses in order to improve vaccine efficacy. MDPI 2022-11-01 /pmc/articles/PMC9693306/ /pubmed/36366363 http://dx.doi.org/10.3390/vaccines10111855 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Yufen Guo, Tong Zhong, Jiayi Fang, Chuanjun Xiong, Husheng Hu, Zengyun Zhu, Yajuan Tan, Jinlin Liu, Shuang Jing, Qinlong Zhang, Dingmei Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title | Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title_full | Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title_fullStr | Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title_full_unstemmed | Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title_short | Effect of Vaccination Time Intervals on SARS-COV-2 Omicron Variant Strain Infection in Guangzhou: A Real-World Matched Case–Control Study |
title_sort | effect of vaccination time intervals on sars-cov-2 omicron variant strain infection in guangzhou: a real-world matched case–control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693306/ https://www.ncbi.nlm.nih.gov/pubmed/36366363 http://dx.doi.org/10.3390/vaccines10111855 |
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