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Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis

Magnetic resonance imaging (MRI) is an important non-invasive examination in the early diagnosis of juvenile dermatomyositis (JDM). We aimed to evaluate the feasibility of radiomics to establish a quantitative analysis of MRI images. Radiomics and machine learning were used to retrospectively analyz...

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Autores principales: Hu, Minfei, Zheng, Fei, Ma, Xiaohui, Liu, Linke, Shen, Chencong, Wu, Jianqiang, Wang, Chaoying, Yang, Li, Xu, Yiping, Zou, Lixia, Fei, Ling, Lu, Meiping, Xu, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693341/
https://www.ncbi.nlm.nih.gov/pubmed/36431189
http://dx.doi.org/10.3390/jcm11226712
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author Hu, Minfei
Zheng, Fei
Ma, Xiaohui
Liu, Linke
Shen, Chencong
Wu, Jianqiang
Wang, Chaoying
Yang, Li
Xu, Yiping
Zou, Lixia
Fei, Ling
Lu, Meiping
Xu, Xuefeng
author_facet Hu, Minfei
Zheng, Fei
Ma, Xiaohui
Liu, Linke
Shen, Chencong
Wu, Jianqiang
Wang, Chaoying
Yang, Li
Xu, Yiping
Zou, Lixia
Fei, Ling
Lu, Meiping
Xu, Xuefeng
author_sort Hu, Minfei
collection PubMed
description Magnetic resonance imaging (MRI) is an important non-invasive examination in the early diagnosis of juvenile dermatomyositis (JDM). We aimed to evaluate the feasibility of radiomics to establish a quantitative analysis of MRI images. Radiomics and machine learning were used to retrospectively analyze MRI T2 fat suppression sequences and relevant clinical data. The model associated with radiomics features was established using a cohort of patients who underwent thigh MRI at the children’s hospital from June 2014 to September 2021. In total, 75 patients with JDM and 75 control children were included in the training cohort (n = 102) and validation cohort (n = 48). The independent factors including lower muscle strength (OR, 0.75; 95% CI, 0.59–0.90), higher creatine kinase (CK) level (OR, 1.65; 95% CI, 1.20–2.38), and higher radiomics score (OR, 2.30; 95% CI, 1.63–3.62) were associated with a clinical diagnosis of JDM. The combined model achieved good discrimination performance compared the radiomics score model under linear discriminant analyses in the training cohort (AUC, 0.949; 95% CI, 0.912–0.986 vs. AUC, 0.912; 95% CI, 0.858–0.967; p = 0.02) and in the validation cohort (AUC, 0.945; 95% CI, 0.878–1 vs. AUC, 0.905; 95% CI, 0.812–0.998; p = 0.03). The combined model showed the diagnostic value was not weaker than the biopsy (AUC, 0.950; 95% CI, 0.919–0.981, n = 150 vs. AUC, 0.952; 95% CI, 0.889–1, n = 72; p = 0.95) and electromyogram (EMG) (AUC, 0.950; 95% CI, 0.919–0.981 vs. AUC, 0.900; 95% CI, 0.852–0.948; p = 0.10) among all the patients. The combination of radiomics features extracted from the MRI and non-invasive clinical characteristics obtained a pronounced discriminative performance to assist in discriminating JDM.
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spelling pubmed-96933412022-11-26 Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis Hu, Minfei Zheng, Fei Ma, Xiaohui Liu, Linke Shen, Chencong Wu, Jianqiang Wang, Chaoying Yang, Li Xu, Yiping Zou, Lixia Fei, Ling Lu, Meiping Xu, Xuefeng J Clin Med Article Magnetic resonance imaging (MRI) is an important non-invasive examination in the early diagnosis of juvenile dermatomyositis (JDM). We aimed to evaluate the feasibility of radiomics to establish a quantitative analysis of MRI images. Radiomics and machine learning were used to retrospectively analyze MRI T2 fat suppression sequences and relevant clinical data. The model associated with radiomics features was established using a cohort of patients who underwent thigh MRI at the children’s hospital from June 2014 to September 2021. In total, 75 patients with JDM and 75 control children were included in the training cohort (n = 102) and validation cohort (n = 48). The independent factors including lower muscle strength (OR, 0.75; 95% CI, 0.59–0.90), higher creatine kinase (CK) level (OR, 1.65; 95% CI, 1.20–2.38), and higher radiomics score (OR, 2.30; 95% CI, 1.63–3.62) were associated with a clinical diagnosis of JDM. The combined model achieved good discrimination performance compared the radiomics score model under linear discriminant analyses in the training cohort (AUC, 0.949; 95% CI, 0.912–0.986 vs. AUC, 0.912; 95% CI, 0.858–0.967; p = 0.02) and in the validation cohort (AUC, 0.945; 95% CI, 0.878–1 vs. AUC, 0.905; 95% CI, 0.812–0.998; p = 0.03). The combined model showed the diagnostic value was not weaker than the biopsy (AUC, 0.950; 95% CI, 0.919–0.981, n = 150 vs. AUC, 0.952; 95% CI, 0.889–1, n = 72; p = 0.95) and electromyogram (EMG) (AUC, 0.950; 95% CI, 0.919–0.981 vs. AUC, 0.900; 95% CI, 0.852–0.948; p = 0.10) among all the patients. The combination of radiomics features extracted from the MRI and non-invasive clinical characteristics obtained a pronounced discriminative performance to assist in discriminating JDM. MDPI 2022-11-13 /pmc/articles/PMC9693341/ /pubmed/36431189 http://dx.doi.org/10.3390/jcm11226712 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Minfei
Zheng, Fei
Ma, Xiaohui
Liu, Linke
Shen, Chencong
Wu, Jianqiang
Wang, Chaoying
Yang, Li
Xu, Yiping
Zou, Lixia
Fei, Ling
Lu, Meiping
Xu, Xuefeng
Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title_full Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title_fullStr Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title_full_unstemmed Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title_short Assessment of Thigh MRI Radiomics and Clinical Characteristics for Assisting in Discrimination of Juvenile Dermatomyositis
title_sort assessment of thigh mri radiomics and clinical characteristics for assisting in discrimination of juvenile dermatomyositis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693341/
https://www.ncbi.nlm.nih.gov/pubmed/36431189
http://dx.doi.org/10.3390/jcm11226712
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