DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve

Chemotherapy regimens and radiotherapy are common strategies to fight cancer. In women, these therapies may cause side effects such as premature ovarian insufficiency (POI) and infertility. Clinical strategies to protect the ovarian reserve from the lethal effect of cancer therapies needs better und...

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Autores principales: Gonfloni, Stefania, Jodice, Carla, Gustavino, Bianca, Valentini, Elvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693393/
https://www.ncbi.nlm.nih.gov/pubmed/36430860
http://dx.doi.org/10.3390/ijms232214379
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author Gonfloni, Stefania
Jodice, Carla
Gustavino, Bianca
Valentini, Elvia
author_facet Gonfloni, Stefania
Jodice, Carla
Gustavino, Bianca
Valentini, Elvia
author_sort Gonfloni, Stefania
collection PubMed
description Chemotherapy regimens and radiotherapy are common strategies to fight cancer. In women, these therapies may cause side effects such as premature ovarian insufficiency (POI) and infertility. Clinical strategies to protect the ovarian reserve from the lethal effect of cancer therapies needs better understanding of the mechanisms underlying iatrogenic loss of follicle reserve. Recent reports demonstrate a critical role for p53 and CHK2 in the oocyte response to different DNA stressors, which are commonly used to treat cancer. Here we review the molecular mechanisms underlying the DNA damage stress response (DDR) and discuss crosstalk between DDR and signaling pathways implicated in primordial follicle activation.
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spelling pubmed-96933932022-11-26 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve Gonfloni, Stefania Jodice, Carla Gustavino, Bianca Valentini, Elvia Int J Mol Sci Review Chemotherapy regimens and radiotherapy are common strategies to fight cancer. In women, these therapies may cause side effects such as premature ovarian insufficiency (POI) and infertility. Clinical strategies to protect the ovarian reserve from the lethal effect of cancer therapies needs better understanding of the mechanisms underlying iatrogenic loss of follicle reserve. Recent reports demonstrate a critical role for p53 and CHK2 in the oocyte response to different DNA stressors, which are commonly used to treat cancer. Here we review the molecular mechanisms underlying the DNA damage stress response (DDR) and discuss crosstalk between DDR and signaling pathways implicated in primordial follicle activation. MDPI 2022-11-19 /pmc/articles/PMC9693393/ /pubmed/36430860 http://dx.doi.org/10.3390/ijms232214379 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gonfloni, Stefania
Jodice, Carla
Gustavino, Bianca
Valentini, Elvia
DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title_full DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title_fullStr DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title_full_unstemmed DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title_short DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
title_sort dna damage stress response and follicle activation: signaling routes of mammalian ovarian reserve
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693393/
https://www.ncbi.nlm.nih.gov/pubmed/36430860
http://dx.doi.org/10.3390/ijms232214379
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