Cargando…
Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693419/ https://www.ncbi.nlm.nih.gov/pubmed/36355116 http://dx.doi.org/10.3390/metabo12111033 |
_version_ | 1784837537022345216 |
---|---|
author | Dugandzic, Mary Kimberly Pierre-Michel, Esther-Carine Kalayjian, Tro |
author_facet | Dugandzic, Mary Kimberly Pierre-Michel, Esther-Carine Kalayjian, Tro |
author_sort | Dugandzic, Mary Kimberly |
collection | PubMed |
description | Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used to diagnose and differentiate between CD and CS. Hypercortisolism has been found to cause many metabolic abnormalities including hypertension, hyperlipidemia, impaired glucose tolerance, and central adiposity. Literature shows that many of the symptoms of hypercortisolism can improve with a low carb (LC) diet, which consists of consuming <30 g of total carbohydrates per day. Here, we describe the case of a patient with CD who presented with obesity, hypertension, striae and bruising, who initially improved some of his symptoms by implementing a LC diet. Ultimately, as his symptoms persisted, a diagnosis of CD was made. It is imperative that practitioners realize that diseases typically associated with poor lifestyle choices, like obesity and hypertension, can often have alternative causes. The goal of this case report is to provide insight on the efficacy of nutrition, specifically a LC diet, on reducing metabolic derangements associated with CD. Additionally, we will discuss the importance of maintaining a high index of suspicion for CD, especially in those with resistant hypertension, obesity and pre-diabetes/diabetes. |
format | Online Article Text |
id | pubmed-9693419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96934192022-11-26 Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease Dugandzic, Mary Kimberly Pierre-Michel, Esther-Carine Kalayjian, Tro Metabolites Case Report Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used to diagnose and differentiate between CD and CS. Hypercortisolism has been found to cause many metabolic abnormalities including hypertension, hyperlipidemia, impaired glucose tolerance, and central adiposity. Literature shows that many of the symptoms of hypercortisolism can improve with a low carb (LC) diet, which consists of consuming <30 g of total carbohydrates per day. Here, we describe the case of a patient with CD who presented with obesity, hypertension, striae and bruising, who initially improved some of his symptoms by implementing a LC diet. Ultimately, as his symptoms persisted, a diagnosis of CD was made. It is imperative that practitioners realize that diseases typically associated with poor lifestyle choices, like obesity and hypertension, can often have alternative causes. The goal of this case report is to provide insight on the efficacy of nutrition, specifically a LC diet, on reducing metabolic derangements associated with CD. Additionally, we will discuss the importance of maintaining a high index of suspicion for CD, especially in those with resistant hypertension, obesity and pre-diabetes/diabetes. MDPI 2022-10-28 /pmc/articles/PMC9693419/ /pubmed/36355116 http://dx.doi.org/10.3390/metabo12111033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Dugandzic, Mary Kimberly Pierre-Michel, Esther-Carine Kalayjian, Tro Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title | Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title_full | Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title_fullStr | Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title_full_unstemmed | Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title_short | Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease |
title_sort | ketogenic diet initially masks symptoms of hypercortisolism in cushing’s disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693419/ https://www.ncbi.nlm.nih.gov/pubmed/36355116 http://dx.doi.org/10.3390/metabo12111033 |
work_keys_str_mv | AT dugandzicmarykimberly ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease AT pierremichelesthercarine ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease AT kalayjiantro ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease |