Cargando…

Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease

Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used...

Descripción completa

Detalles Bibliográficos
Autores principales: Dugandzic, Mary Kimberly, Pierre-Michel, Esther-Carine, Kalayjian, Tro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693419/
https://www.ncbi.nlm.nih.gov/pubmed/36355116
http://dx.doi.org/10.3390/metabo12111033
_version_ 1784837537022345216
author Dugandzic, Mary Kimberly
Pierre-Michel, Esther-Carine
Kalayjian, Tro
author_facet Dugandzic, Mary Kimberly
Pierre-Michel, Esther-Carine
Kalayjian, Tro
author_sort Dugandzic, Mary Kimberly
collection PubMed
description Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used to diagnose and differentiate between CD and CS. Hypercortisolism has been found to cause many metabolic abnormalities including hypertension, hyperlipidemia, impaired glucose tolerance, and central adiposity. Literature shows that many of the symptoms of hypercortisolism can improve with a low carb (LC) diet, which consists of consuming <30 g of total carbohydrates per day. Here, we describe the case of a patient with CD who presented with obesity, hypertension, striae and bruising, who initially improved some of his symptoms by implementing a LC diet. Ultimately, as his symptoms persisted, a diagnosis of CD was made. It is imperative that practitioners realize that diseases typically associated with poor lifestyle choices, like obesity and hypertension, can often have alternative causes. The goal of this case report is to provide insight on the efficacy of nutrition, specifically a LC diet, on reducing metabolic derangements associated with CD. Additionally, we will discuss the importance of maintaining a high index of suspicion for CD, especially in those with resistant hypertension, obesity and pre-diabetes/diabetes.
format Online
Article
Text
id pubmed-9693419
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96934192022-11-26 Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease Dugandzic, Mary Kimberly Pierre-Michel, Esther-Carine Kalayjian, Tro Metabolites Case Report Cushing’s syndrome (CS) is a diagnosis used to describe multiple causes of serum hypercortisolism. Cushing’s disease (CD), the most common endogenous subtype of CS, is characterized by hypercortisolism due to a pituitary tumor secreting adrenocorticotropic hormone (ACTH). A variety of tests are used to diagnose and differentiate between CD and CS. Hypercortisolism has been found to cause many metabolic abnormalities including hypertension, hyperlipidemia, impaired glucose tolerance, and central adiposity. Literature shows that many of the symptoms of hypercortisolism can improve with a low carb (LC) diet, which consists of consuming <30 g of total carbohydrates per day. Here, we describe the case of a patient with CD who presented with obesity, hypertension, striae and bruising, who initially improved some of his symptoms by implementing a LC diet. Ultimately, as his symptoms persisted, a diagnosis of CD was made. It is imperative that practitioners realize that diseases typically associated with poor lifestyle choices, like obesity and hypertension, can often have alternative causes. The goal of this case report is to provide insight on the efficacy of nutrition, specifically a LC diet, on reducing metabolic derangements associated with CD. Additionally, we will discuss the importance of maintaining a high index of suspicion for CD, especially in those with resistant hypertension, obesity and pre-diabetes/diabetes. MDPI 2022-10-28 /pmc/articles/PMC9693419/ /pubmed/36355116 http://dx.doi.org/10.3390/metabo12111033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Dugandzic, Mary Kimberly
Pierre-Michel, Esther-Carine
Kalayjian, Tro
Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title_full Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title_fullStr Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title_full_unstemmed Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title_short Ketogenic Diet Initially Masks Symptoms of Hypercortisolism in Cushing’s Disease
title_sort ketogenic diet initially masks symptoms of hypercortisolism in cushing’s disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693419/
https://www.ncbi.nlm.nih.gov/pubmed/36355116
http://dx.doi.org/10.3390/metabo12111033
work_keys_str_mv AT dugandzicmarykimberly ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease
AT pierremichelesthercarine ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease
AT kalayjiantro ketogenicdietinitiallymaskssymptomsofhypercortisolismincushingsdisease