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Application of Physiologically Based Pharmacokinetic Modeling to Predict Maternal Pharmacokinetics and Fetal Exposure to Oxcarbazepine

Pregnancy is associated with physiological changes that may affect drug pharmacokinetics (PKs). The aim of this study was to establish a maternal–fetal physiologically based pharmacokinetic (PBPK) model of oxcarbazepine (OXC) and its active metabolite, 10,11-dihydro-10-hydroxy-carbazepine (MHD), to...

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Detalles Bibliográficos
Autores principales:	He, Lixia, Ke, Meng, Wu, Wanhong, Chen, Jiarui, Guo, Guimu, Lin, Rongfang, Huang, Pinfang, Lin, Cuihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693517/ https://www.ncbi.nlm.nih.gov/pubmed/36365185 http://dx.doi.org/10.3390/pharmaceutics14112367

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