Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity

New derivatives of non-steroidal anti-inflammatory drugs were synthesized via conjugation with L-amino acid isopropyl esters. The characteristics of the physicochemical properties of the obtained pharmaceutically active ionic liquids were determined. It has been shown how the incorporation of variou...

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Autores principales: Klebeko, Joanna, Krüger, Oliver, Dubicki, Mateusz, Ossowicz-Rupniewska, Paula, Janus, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693575/
https://www.ncbi.nlm.nih.gov/pubmed/36430346
http://dx.doi.org/10.3390/ijms232213863
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author Klebeko, Joanna
Krüger, Oliver
Dubicki, Mateusz
Ossowicz-Rupniewska, Paula
Janus, Ewa
author_facet Klebeko, Joanna
Krüger, Oliver
Dubicki, Mateusz
Ossowicz-Rupniewska, Paula
Janus, Ewa
author_sort Klebeko, Joanna
collection PubMed
description New derivatives of non-steroidal anti-inflammatory drugs were synthesized via conjugation with L-amino acid isopropyl esters. The characteristics of the physicochemical properties of the obtained pharmaceutically active ionic liquids were determined. It has been shown how the incorporation of various L-amino acid esters as an ion pair affects the properties of the parent drug. Moreover, the antimicrobial activity of the obtained compounds was evaluated. The proposed structural modifications of commonly used drugs indicate great potential for use in topical and transdermal preparations.
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spelling pubmed-96935752022-11-26 Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity Klebeko, Joanna Krüger, Oliver Dubicki, Mateusz Ossowicz-Rupniewska, Paula Janus, Ewa Int J Mol Sci Article New derivatives of non-steroidal anti-inflammatory drugs were synthesized via conjugation with L-amino acid isopropyl esters. The characteristics of the physicochemical properties of the obtained pharmaceutically active ionic liquids were determined. It has been shown how the incorporation of various L-amino acid esters as an ion pair affects the properties of the parent drug. Moreover, the antimicrobial activity of the obtained compounds was evaluated. The proposed structural modifications of commonly used drugs indicate great potential for use in topical and transdermal preparations. MDPI 2022-11-10 /pmc/articles/PMC9693575/ /pubmed/36430346 http://dx.doi.org/10.3390/ijms232213863 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Klebeko, Joanna
Krüger, Oliver
Dubicki, Mateusz
Ossowicz-Rupniewska, Paula
Janus, Ewa
Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title_full Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title_fullStr Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title_full_unstemmed Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title_short Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
title_sort isopropyl amino acid esters ionic liquids as vehicles for non-steroidal anti-inflammatory drugs in potential topical drug delivery systems with antimicrobial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693575/
https://www.ncbi.nlm.nih.gov/pubmed/36430346
http://dx.doi.org/10.3390/ijms232213863
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