MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis

MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptid...

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Detalles Bibliográficos
Autores principales: Kim, Se-Jin, Karamooz, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693577/
https://www.ncbi.nlm.nih.gov/pubmed/36430890
http://dx.doi.org/10.3390/ijms232214412
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author Kim, Se-Jin
Karamooz, Elham
author_facet Kim, Se-Jin
Karamooz, Elham
author_sort Kim, Se-Jin
collection PubMed
description MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.
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spelling pubmed-96935772022-11-26 MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis Kim, Se-Jin Karamooz, Elham Int J Mol Sci Review MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection. MDPI 2022-11-19 /pmc/articles/PMC9693577/ /pubmed/36430890 http://dx.doi.org/10.3390/ijms232214412 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Se-Jin
Karamooz, Elham
MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title_full MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title_fullStr MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title_full_unstemmed MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title_short MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
title_sort mr1- and hla-e-dependent antigen presentation of mycobacterium tuberculosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693577/
https://www.ncbi.nlm.nih.gov/pubmed/36430890
http://dx.doi.org/10.3390/ijms232214412
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AT karamoozelham mr1andhlaedependentantigenpresentationofmycobacteriumtuberculosis

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