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Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy

Neurogenic muscle atrophy is a debilitating condition that occurs from nerve trauma in association with diseases or during aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches aiming at preserving muscle mass in a scenario of decreased nervous...

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Autores principales: Moresi, Viviana, Renzini, Alessandra, Cavioli, Giorgia, Seelaender, Marilia, Coletti, Dario, Gigli, Giuseppe, Cedola, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693586/
https://www.ncbi.nlm.nih.gov/pubmed/36422289
http://dx.doi.org/10.3390/metabo12111149
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author Moresi, Viviana
Renzini, Alessandra
Cavioli, Giorgia
Seelaender, Marilia
Coletti, Dario
Gigli, Giuseppe
Cedola, Alessia
author_facet Moresi, Viviana
Renzini, Alessandra
Cavioli, Giorgia
Seelaender, Marilia
Coletti, Dario
Gigli, Giuseppe
Cedola, Alessia
author_sort Moresi, Viviana
collection PubMed
description Neurogenic muscle atrophy is a debilitating condition that occurs from nerve trauma in association with diseases or during aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches aiming at preserving muscle mass in a scenario of decreased nervous input include physical activity and employment of drugs that slow down the progression of the condition yet provide no concrete resolution. Nutritional support appears as a precious tool, adding to the success of personalized medicine, and could thus play a relevant part in mitigating neurogenic muscle atrophy. We herein summarize the molecular pathways triggered by denervation of the skeletal muscle that could be affected by functional nutrients. In this narrative review, we examine and discuss studies pertaining to the use of functional ingredients to counteract neurogenic muscle atrophy, focusing on their preventive or curative means of action within the skeletal muscle. We reviewed experimental models of denervation in rodents and in amyotrophic lateral sclerosis, as well as that caused by aging, considering the knowledge generated with use of animal experimental models and, also, from human studies.
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spelling pubmed-96935862022-11-26 Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy Moresi, Viviana Renzini, Alessandra Cavioli, Giorgia Seelaender, Marilia Coletti, Dario Gigli, Giuseppe Cedola, Alessia Metabolites Review Neurogenic muscle atrophy is a debilitating condition that occurs from nerve trauma in association with diseases or during aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches aiming at preserving muscle mass in a scenario of decreased nervous input include physical activity and employment of drugs that slow down the progression of the condition yet provide no concrete resolution. Nutritional support appears as a precious tool, adding to the success of personalized medicine, and could thus play a relevant part in mitigating neurogenic muscle atrophy. We herein summarize the molecular pathways triggered by denervation of the skeletal muscle that could be affected by functional nutrients. In this narrative review, we examine and discuss studies pertaining to the use of functional ingredients to counteract neurogenic muscle atrophy, focusing on their preventive or curative means of action within the skeletal muscle. We reviewed experimental models of denervation in rodents and in amyotrophic lateral sclerosis, as well as that caused by aging, considering the knowledge generated with use of animal experimental models and, also, from human studies. MDPI 2022-11-21 /pmc/articles/PMC9693586/ /pubmed/36422289 http://dx.doi.org/10.3390/metabo12111149 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moresi, Viviana
Renzini, Alessandra
Cavioli, Giorgia
Seelaender, Marilia
Coletti, Dario
Gigli, Giuseppe
Cedola, Alessia
Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title_full Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title_fullStr Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title_full_unstemmed Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title_short Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
title_sort functional nutrients to ameliorate neurogenic muscle atrophy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693586/
https://www.ncbi.nlm.nih.gov/pubmed/36422289
http://dx.doi.org/10.3390/metabo12111149
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