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Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa

A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (Mops condylurus, family Molossidae) captured in Tanzania and in one free-tailed bat in the Democratic Republic of Congo. Hantavirus RNA was found in different organs, with the highest loads in the splee...

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Autores principales: Weiss, Sabrina, Sudi, Lwitiho E., Düx, Ariane, Mangu, Chacha D., Ntinginya, Nyanda Elias, Shirima, Gabriel M., Köndgen, Sophie, Schubert, Grit, Witkowski, Peter T., Muyembe, Jean-Jacques, Ahuka, Steve, Klempa, Boris, Leendertz, Fabian H., Krüger, Detlev H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693593/
https://www.ncbi.nlm.nih.gov/pubmed/36366466
http://dx.doi.org/10.3390/v14112368
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author Weiss, Sabrina
Sudi, Lwitiho E.
Düx, Ariane
Mangu, Chacha D.
Ntinginya, Nyanda Elias
Shirima, Gabriel M.
Köndgen, Sophie
Schubert, Grit
Witkowski, Peter T.
Muyembe, Jean-Jacques
Ahuka, Steve
Klempa, Boris
Leendertz, Fabian H.
Krüger, Detlev H.
author_facet Weiss, Sabrina
Sudi, Lwitiho E.
Düx, Ariane
Mangu, Chacha D.
Ntinginya, Nyanda Elias
Shirima, Gabriel M.
Köndgen, Sophie
Schubert, Grit
Witkowski, Peter T.
Muyembe, Jean-Jacques
Ahuka, Steve
Klempa, Boris
Leendertz, Fabian H.
Krüger, Detlev H.
author_sort Weiss, Sabrina
collection PubMed
description A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (Mops condylurus, family Molossidae) captured in Tanzania and in one free-tailed bat in the Democratic Republic of Congo. Hantavirus RNA was found in different organs, with the highest loads in the spleen. Nucleotide sequences of large parts of the genomic S and L segments were determined by in-solution hybridisation capture and high throughput sequencing. Phylogenetic analyses placed Kiwira virus into the genus Mobatvirus of the family Hantaviridae, with the bat-infecting Quezon virus and Robina virus as closest relatives. The detection of several infected individuals in two African countries, including animals with systemic hantavirus infection, provides evidence of active replication and a stable circulation of Kiwira virus in M. condylurus bats and points to this species as a natural host. Since the M. condylurus home range covers large regions of Sub-Saharan Africa and the species is known to roost inside and around human dwellings, a potential spillover of the Kiwira virus to humans must be considered.
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spelling pubmed-96935932022-11-26 Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa Weiss, Sabrina Sudi, Lwitiho E. Düx, Ariane Mangu, Chacha D. Ntinginya, Nyanda Elias Shirima, Gabriel M. Köndgen, Sophie Schubert, Grit Witkowski, Peter T. Muyembe, Jean-Jacques Ahuka, Steve Klempa, Boris Leendertz, Fabian H. Krüger, Detlev H. Viruses Article A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (Mops condylurus, family Molossidae) captured in Tanzania and in one free-tailed bat in the Democratic Republic of Congo. Hantavirus RNA was found in different organs, with the highest loads in the spleen. Nucleotide sequences of large parts of the genomic S and L segments were determined by in-solution hybridisation capture and high throughput sequencing. Phylogenetic analyses placed Kiwira virus into the genus Mobatvirus of the family Hantaviridae, with the bat-infecting Quezon virus and Robina virus as closest relatives. The detection of several infected individuals in two African countries, including animals with systemic hantavirus infection, provides evidence of active replication and a stable circulation of Kiwira virus in M. condylurus bats and points to this species as a natural host. Since the M. condylurus home range covers large regions of Sub-Saharan Africa and the species is known to roost inside and around human dwellings, a potential spillover of the Kiwira virus to humans must be considered. MDPI 2022-10-27 /pmc/articles/PMC9693593/ /pubmed/36366466 http://dx.doi.org/10.3390/v14112368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Weiss, Sabrina
Sudi, Lwitiho E.
Düx, Ariane
Mangu, Chacha D.
Ntinginya, Nyanda Elias
Shirima, Gabriel M.
Köndgen, Sophie
Schubert, Grit
Witkowski, Peter T.
Muyembe, Jean-Jacques
Ahuka, Steve
Klempa, Boris
Leendertz, Fabian H.
Krüger, Detlev H.
Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title_full Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title_fullStr Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title_full_unstemmed Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title_short Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
title_sort kiwira virus, a newfound hantavirus discovered in free-tailed bats (molossidae) in east and central africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693593/
https://www.ncbi.nlm.nih.gov/pubmed/36366466
http://dx.doi.org/10.3390/v14112368
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