Cargando…

Mechanochemical Approach towards Multi-Functionalized 1,2,3-Triazoles and Anti-Seizure Drug Rufinamide Analogs Using Copper Beads

Highly regiospecific, copper-salt-free and neat conditions have been demonstrated for the 1,3-dipolar azide-alkyne cycloaddition (AAC) reactions under mechanochemical conditions. A group of structurally challenging alkynes and heterocyclic derivatives was efficiently implemented to achieve highly fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacherjee, Dhananjay, Kovalev, Igor S., Kopchuk, Dmitry S., Rahman, Matiur, Santra, Sougata, Zyryanov, Grigory V., Das, Pralay, Purohit, Rituraj, Rusinov, Vladimir L., Chupakhin, Oleg N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693609/ https://www.ncbi.nlm.nih.gov/pubmed/36431885 http://dx.doi.org/10.3390/molecules27227784

Ejemplares similares

Benchmarking the ability of novel compounds to inhibit SARS-CoV-2 main protease using steered molecular dynamics simulations
por: Singh, Rahul, et al.
Publicado: (2022)

Pillararenes as Promising Carriers for Drug Delivery
por: Zyryanov, Grigory V., et al.
Publicado: (2023)

2,7-Diazapyrenes: a brief review on synthetic strategies and application opportunities
por: Mukherjee, Anindita, et al.
Publicado: (2022)

TM-Free and TM-Catalyzed Mechanosynthesis of Functional Polymers
por: Al-Ithawi, Wahab K. A., et al.
Publicado: (2023)

Polymers and Polymer-Based Materials for the Detection of (Nitro-)explosives
por: Taniya, Olga S., et al.
Publicado: (2023)

Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
por: Kovalev, Igor S., et al.
Publicado: (2022)

Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds
por: Rammohan, Aluru, et al.
Publicado: (2022)

Computer vision vs. spectrofluorometer-assisted detection of common nitro-explosive components with bola-type PAH-based chemosensors
por: Kovalev, Igor S., et al.
Publicado: (2021)

Mechanosynthesis of Polyureas and Studies of Their Responses to Anions
por: Al-Ithawi, Wahab K. A., et al.
Publicado: (2023)

Update on rufinamide in childhood epilepsy
por: Coppola, Giangennaro
Publicado: (2011)

Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones
por: Aluru, Rammohan, et al.
Publicado: (2023)

The Efficacy and Tolerability of Rufinamide in Intractable Pediatric Epilepsy
por: Kim, Jae Yeon, et al.
Publicado: (2012)

Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugs
por: Bhardwaj, Vijay Kumar, et al.
Publicado: (2021)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Structural and Synthetic Aspects of Small Ring Oxa- and Aza-Heterocyclic Ring Systems as Antiviral Activities
por: Manna, Sibasish, et al.
Publicado: (2023)

Comparison of Photophysical Properties of Lanthanide(III) Complexes of DTTA- or DO3A-Appended Aryl-2,2′-Bipyridines
por: Krinochkin, Alexey P., et al.
Publicado: (2023)

Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca(2+)-Activated K(+) Currents While Inhibiting Voltage-Gated Na(+) Currents
por: Lai, Ming-Chi, et al.
Publicado: (2022)

Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide
por: Stafstrom, Carl E
Publicado: (2009)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity
por: Santra, Sougata, et al.
Publicado: (2023)

Synthesis and Photophysical Properties of α-(N-Biphenyl)-Substituted 2,2′-Bipyridine-Based Push–Pull Fluorophores
por: Starnovskaya, Ekaterina S., et al.
Publicado: (2022)

Mild, Efficient, and Metal-Free Radical 1,2-Dithiocyanation of Alkynes and Alkenes at Room Temperature
por: Samanta, Satyajit, et al.
Publicado: (2018)

Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy)
por: Kluger, Gerhard, et al.
Publicado: (2007)

Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide
por: Saneto, Russell P, et al.
Publicado: (2009)

Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
por: Balagura, Ganna, et al.
Publicado: (2020)

Polyaromatic Hydrocarbon (PAH)-Based Aza-POPOPs: Synthesis, Photophysical Studies, and Nitroanalyte Sensing Abilities
por: Mohammed, Mohammed S., et al.
Publicado: (2023)

Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide
por: Gresham, Jessica, et al.
Publicado: (2010)

Development and validation of a stability indicating RP-HPLC method for the determination of Rufinamide
por: Sai Pavan Kumar, B., et al.
Publicado: (2013)

A computational approach for rational discovery of inhibitors for non-structural protein 1 of SARS-CoV-2
por: Singh, Rahul, et al.
Publicado: (2021)

1,2,3-Triazoles as Biomimetics in Peptide Science
por: Agouram, Naima, et al.
Publicado: (2021)

Triazole-Bridged Zinc Dinuclear Complexes: Mechanochemical Synthesis, Crystal Structure, and Biological Activity
por: Park, Hee Sun, et al.
Publicado: (2022)

Treatment of Adults with Lennox–Gastaut Syndrome: Further Analysis of Efficacy and Safety/Tolerability of Rufinamide
por: McMurray, Rob, et al.
Publicado: (2016)

New TEMPO–Appended 2,2′-Bipyridine-Based Eu(III), Tb(III), Gd(III) and Sm(III) Complexes: Synthesis, Photophysical Studies and Testing Photoluminescence-Based Bioimaging Abilities
por: Slovesnova, Nataliya V., et al.
Publicado: (2022)

Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles
por: Banday, Abid H, et al.
Publicado: (2012)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

A practical flow synthesis of 1,2,3-triazoles
por: Drelinkiewicz, Dawid, et al.
Publicado: (2022)

Versatile Synthetic Platform for 1,2,3-Triazole Chemistry
por: Vala, Disha P., et al.
Publicado: (2022)

1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
por: Bosch-Sanz, Oriol, et al.
Publicado: (2022)

1,2,3-Triazoles and their metal chelates with antimicrobial activity
por: Todorov, Lozan, et al.
Publicado: (2023)

Fluorescent Pyranoindole Congeners: Synthesis and Photophysical Properties of Pyrano[3,2-f], [2,3-g], [2,3-f], and [2,3-e]Indoles
por: Sharapov, Ainur D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dqeikmosl7cva1f6c86k6l1krn